A Worldwide Survey on Pathological Measurement of Residual Breast Cancer After Neoadjuvant Therapy Different Interpretations of the ypTNM Classification /
The extent of residual disease after neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients holds prognostic value. However, current practices for reporting post-NAC BC specimens according to the ypTNM classification vary. This study aimed to map these practices and provide recommendations fo...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2026
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| Sorozat: | MODERN PATHOLOGY
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| Tárgyszavak: | |
| doi: | 10.1016/j.modpat.2026.100963 |
| mtmt: | 36900232 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/39344 |
| LEADER | 03341nab a2200457 i 4500 | ||
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| 005 | 20260224081929.0 | ||
| 008 | 260224s2026 hu o 000 eng d | ||
| 022 | |a 0893-3952 | ||
| 024 | 7 | |a 10.1016/j.modpat.2026.100963 |2 doi | |
| 024 | 7 | |a 36900232 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kwakkenbos Koen | |
| 245 | 1 | 2 | |a A Worldwide Survey on Pathological Measurement of Residual Breast Cancer After Neoadjuvant Therapy |h [elektronikus dokumentum] : |b Different Interpretations of the ypTNM Classification / |c Kwakkenbos Koen |
| 260 | |c 2026 | ||
| 300 | |a 9 | ||
| 490 | 0 | |a MODERN PATHOLOGY | |
| 520 | 3 | |a The extent of residual disease after neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients holds prognostic value. However, current practices for reporting post-NAC BC specimens according to the ypTNM classification vary. This study aimed to map these practices and provide recommendations for standardization. A survey was developed and globally circulated to pathologists with a special interest in BC through personal networks and working group mailing lists. The survey included general questions about tumor diameter assessment, as well as graphical scenarios presenting different distributions of tumor cells. We did not provide definitions mentioned in reporting guidelines to capture unbiased current real-world practices. A total of 208 pathologists from 35 countries completed the survey. Almost all responding pathologists (97.1%) report the ypTNM in daily practice. Despite self-reported strict adherence to the 8th edition of the international ypTNM classification, we found substantial variation in practice concerning the application of this staging system, particularly in cases with an uneven distribution of scattered residual disease. Notably, 57.2% of respondents reported measuring the largest 'continuous cluster of tumor cells', but the interpretation of this definition varied widely. This international survey identifies the challenges and the practice heterogeneity in the current application of the ypTNM staging system, which hampers the value of ypTNM reporting in daily practice. To enhance reproducibility and to provide more reliable post-NAC risk stratification, we recommend adopting standardized reporting with clearer pattern-based definitions of the ypTNM guidelines, supplemented with the elements of the Residual Cancer Burden system. | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 2 | |a Van Bockstal Mieke R. |e aut |
| 700 | 0 | 2 | |a Shaaban Abeer M. |e aut |
| 700 | 0 | 2 | |a Brogi Edi |e aut |
| 700 | 0 | 2 | |a Cserni Gábor |e aut |
| 700 | 0 | 2 | |a Ellis Ian O. |e aut |
| 700 | 0 | 2 | |a Foschini Maria Pia |e aut |
| 700 | 0 | 2 | |a Fox Stephen B. |e aut |
| 700 | 0 | 2 | |a Bago-Horvath Zsuzsanna |e aut |
| 700 | 0 | 2 | |a Jaffer Shabnam |e aut |
| 700 | 0 | 2 | |a Jager Agnes |e aut |
| 700 | 0 | 2 | |a Pinder Sarah E. |e aut |
| 700 | 0 | 2 | |a Provenzano Elena |e aut |
| 700 | 0 | 2 | |a Quinn Cecily M. |e aut |
| 700 | 0 | 2 | |a Rakha Emad A. |e aut |
| 700 | 0 | 2 | |a Raymond Wendy A. |e aut |
| 700 | 0 | 2 | |a Tan Puay Hoon |e aut |
| 700 | 0 | 2 | |a Tse Gary M. |e aut |
| 700 | 0 | 2 | |a Varga Zsuzsanna |e aut |
| 700 | 0 | 2 | |a Wen Hannah Y. |e aut |
| 700 | 0 | 2 | |a van Deurzen Carolien H. M. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/39344/1/ModPathol-2026-39-100963-KwakkenbosK-ypT.pdf |z Dokumentum-elérés |