Correlated Multimodal Imaging in Bone Regeneration - A Showcase of Bisphosphonate-Treated Murine Jawbones
The bone is a tissue that is capable of repair and regeneration in response to traumatic injuries. However, bone diseases have become a serious health issue worldwide caused by a variety of factors including poor diet, trauma, cancer, infection, and inflammations to name a few. Bisphosphonate (BIS)-...
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| Dokumentumtípus: | Könyv része |
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Springer Nature Switzerland
Cham
2025
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| Sorozat: | Reference Series in Biomedical Engineering
Bioimaging in tissue engineering and regeneration : advanced microscopy and preclinical imaging |
| Tárgyszavak: | |
| doi: | 10.1007/978-3-031-91544-4_12 |
| mtmt: | 36298800 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/39170 |
| LEADER | 03079naa a2200289 i 4500 | ||
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| 001 | publ39170 | ||
| 005 | 20260216133830.0 | ||
| 008 | 260216s2025 hu o 000 eng d | ||
| 020 | |a 9783031915444; 9783031915437 | ||
| 024 | 7 | |a 10.1007/978-3-031-91544-4_12 |2 doi | |
| 024 | 7 | |a 36298800 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bhattacharjee Piyali | |
| 245 | 1 | 0 | |a Correlated Multimodal Imaging in Bone Regeneration - A Showcase of Bisphosphonate-Treated Murine Jawbones |h [elektronikus dokumentum] / |c Bhattacharjee Piyali |
| 260 | |a Springer Nature Switzerland |b Cham |c 2025 | ||
| 300 | |a 45 | ||
| 300 | |a 259-303 | ||
| 490 | 0 | |a Reference Series in Biomedical Engineering | |
| 490 | 0 | |a Bioimaging in tissue engineering and regeneration : advanced microscopy and preclinical imaging | |
| 520 | 3 | |a The bone is a tissue that is capable of repair and regeneration in response to traumatic injuries. However, bone diseases have become a serious health issue worldwide caused by a variety of factors including poor diet, trauma, cancer, infection, and inflammations to name a few. Bisphosphonate (BIS)-related osteonecrosis of the jaw (BRONJ) is a medication-induced bone disorder which manifests as non-healing exposed bone involving the maxillofacial structures. For a more detailed characterization of BRONJ and potential treatments and its diagnosis, correlated multimodal imaging (CMI) can provide holistic and multiscale information about the disease model. This book chapter discusses in depth the current CMI techniques employed to study bone disorders and their regeneration. The focus of this chapter is to showcase the establishment of a CMI pipeline to characterize BIS-treated jawbones of Sprague-Dawley rats after tooth extraction and the role of physical therapies, such as photobiomodulation (PBMT) and extracorporeal shockwave therapy (ESWT) in tackling BRONJ. Combining micro-computed tomography (μCT), micro-X-Ray Fluorescence Spectroscopy (μXRF), Atomic Force Microscopy (AFM) and scanning electron microscopy (SEM), the feasibility of such a CMI approach and its compatibility across imaging modalities to probe the same region of interest (ROI) of the same jawbone has been demonstrated. The combination of these four modalities provided multiscale information on the morphology, topography, mechanical stiffness and elemental (calcium, zinc, and phosphorus) composition of the bone and helped to compare the jawbones of a previously published clinically relevant rat model of BRONJ before and after treatment with BISs, PBMT, and ESWT. In future, the established CMI platform can be used to study other bone-related disorders such as osteoarthritis, −porosis, or necrosis and help to better characterize disease status and mitigation strategies. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Szabó Andrea |e aut |
| 700 | 0 | 1 | |a Dungel Peter |e aut |
| 700 | 0 | 1 | |a Streli Christina |e aut |
| 700 | 0 | 1 | |a Walter Andreas |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/39170/1/PBhattarcharjeeASzabo.pdf |z Dokumentum-elérés |