Duodenal Foveolar Adenoma Case Presentation with Whole Exome Sequencing and Review of the Literature : [case report] /
Introduction: Duodenal adenomas are most commonly associated with polyposis syndromes. Foveolar adenoma is an especially rare entity with an unknown aetiology. We present a case of duodenal foveolar adenoma with coexisting metaplasia, whole exome sequencing results, and the first literature review.C...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
|
| Sorozat: | PATHOBIOLOGY
92 |
| Tárgyszavak: | |
| doi: | 10.1159/000546139 |
| mtmt: | 36169705 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/37419 |
| LEADER | 02155nab a2200289 i 4500 | ||
|---|---|---|---|
| 001 | publ37419 | ||
| 005 | 20251003144105.0 | ||
| 008 | 250808s2025 hu o 000 eng d | ||
| 022 | |a 1015-2008 | ||
| 024 | 7 | |a 10.1159/000546139 |2 doi | |
| 024 | 7 | |a 36169705 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ferenczi Ádám | |
| 245 | 1 | 0 | |a Duodenal Foveolar Adenoma |h [elektronikus dokumentum] : |b Case Presentation with Whole Exome Sequencing and Review of the Literature : [case report] / |c Ferenczi Ádám |
| 260 | |c 2025 | ||
| 300 | |a 300-305 | ||
| 490 | 0 | |a PATHOBIOLOGY |v 92 | |
| 520 | 3 | |a Introduction: Duodenal adenomas are most commonly associated with polyposis syndromes. Foveolar adenoma is an especially rare entity with an unknown aetiology. We present a case of duodenal foveolar adenoma with coexisting metaplasia, whole exome sequencing results, and the first literature review.Case presentation: Hereby we present the case of a 58-year-old man, whose polypectomy specimen revealed a lesion composed of mainly foveolar cells with low-grade dysplasia, and was concluded as foveolar adenoma. Due to the incomplete resection, polypectomy was repeated, this time foveolar adenoma was diagnosed with high-grade dysplasia. Foveolar differentiation was proved with MUC5AC immunohistochemistry, in addition, KRAS and SMAD4 pathogenic mutations were identified.Discussion: Duodenal foveolar adenoma remains a controversial and an enigmatic entity. Our paper presents such a lesion with first low-grade, then high-grade dysplasia, and KRAS mutation, identical to gastric manifestations. The further sample of our patient suggests foveolar metaplasia as an aetiological factor that supports the literature data. | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Germano Sofia |e aut |
| 700 | 0 | 1 | |a Afonso Joana |e aut |
| 700 | 0 | 1 | |a Kuthi Levente |e aut |
| 700 | 0 | 1 | |a Lantos Tamás |e aut |
| 700 | 0 | 1 | |a Sejben Anita |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/37419/7/36169705.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/37419/1/43_Foveolaradenoma_Pathobiology.pdf |z Dokumentum-elérés |