Protective Effect of a Hexapeptide Derived from Rotifer-Specific SCO-Spondin Against Beta-Amyloid Toxicity
The Rotimer (rotifer-specific biopolymer) like SCO-spondin (R-SSPO/1), predicted as the main component of this biopolymer, is an adequate base for the design of functional small peptides. This macromolecule is interactive and protective against neurotoxic human-type beta-amyloid 1-42 aggregates (agg...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
26 No. 11 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms26115109 |
| mtmt: | 36194786 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/37256 |
| LEADER | 02536nab a2200313 i 4500 | ||
|---|---|---|---|
| 001 | publ37256 | ||
| 005 | 20250716093638.0 | ||
| 008 | 250716s2025 hu o 000 eng d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms26115109 |2 doi | |
| 024 | 7 | |a 36194786 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Datki Zsolt László | |
| 245 | 1 | 0 | |a Protective Effect of a Hexapeptide Derived from Rotifer-Specific SCO-Spondin Against Beta-Amyloid Toxicity |h [elektronikus dokumentum] / |c Datki Zsolt László |
| 260 | |c 2025 | ||
| 300 | |a 16 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 26 No. 11 | |
| 520 | 3 | |a The Rotimer (rotifer-specific biopolymer) like SCO-spondin (R-SSPO/1), predicted as the main component of this biopolymer, is an adequate base for the design of functional small peptides. This macromolecule is interactive and protective against neurotoxic human-type beta-amyloid 1-42 aggregates (agg-Abeta). The current work presents biological investigations and predictable molecular interaction analysis of DSSNDL and PNCRDGSDE peptides that were synthesized based on the sequences of R-SSPO/1. Viability assays (NADH-dependent cellular reduction capacity, intracellular esterase activity, and motility) were performed on differentiated neuro-type cell cultures (SH-SY5Y and PC12) and on Rotimer-depleted rotifers (Euchlanis dilatata and Lecane bulla). A control peptide (STTRPTGTT), not found in Rotimer, was also included in the study. All three peptides are present in both rotifer and human proteomes. Among these small molecules, DSSNDL showed a significant protective effect against the toxicity of agg-Abeta both in vitro and in vivo and presumably interacted with its aggregates. The stagogram analysis of amyloid-peptide complexes and the possible bonding competition of these small molecules against aggregation-specific dyes on agg-Abeta surface suggest that DSSNDL affects the properties of these neurotoxic macromolecules. This effective hexapeptide can serve as a promising candidate for further investigations into the inactivation of beta-amyloid toxicity. | |
| 650 | 4 | |a Kémiai tudományok | |
| 650 | 4 | |a Biológiai tudományok | |
| 700 | 0 | 1 | |a Sinka Rita |e aut |
| 700 | 0 | 1 | |a Dingmann Brian J |e aut |
| 700 | 0 | 1 | |a Gálik Bence |e aut |
| 700 | 0 | 1 | |a Szabó Antal |e aut |
| 700 | 0 | 2 | |a Galik-Olah Zita |e aut |
| 700 | 0 | 2 | |a Tóth Gábor |e aut |
| 700 | 0 | 2 | |a Bozsó Zsolt |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/37256/1/datki_et_al_2025.pdf |z Dokumentum-elérés |