Differential Myocardial Responses in Male and Female Rats with Uremic Cardiomyopathy
Uremic cardiomyopathy, characterized by diastolic dysfunction, left ventricular hypertrophy (LVH), and fibrosis, is a common cardiovascular complication of chronic kidney disease (CKD). Men are at a higher risk for cardiovascular and renal diseases, compared to age-matched, pre-menopausal women. We...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
26 No. 5 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms26052259 |
| mtmt: | 35806596 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/36221 |
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| 008 | 250306s2025 hu o 000 eng d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms26052259 |2 doi | |
| 024 | 7 | |a 35806596 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bódi Beáta | |
| 245 | 1 | 0 | |a Differential Myocardial Responses in Male and Female Rats with Uremic Cardiomyopathy |h [elektronikus dokumentum] / |c Bódi Beáta |
| 260 | |c 2025 | ||
| 300 | |a 20 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 26 No. 5 | |
| 520 | 3 | |a Uremic cardiomyopathy, characterized by diastolic dysfunction, left ventricular hypertrophy (LVH), and fibrosis, is a common cardiovascular complication of chronic kidney disease (CKD). Men are at a higher risk for cardiovascular and renal diseases, compared to age-matched, pre-menopausal women. We aimed to investigate the influence of sex on the severity of uremic cardiomyopathy through the characterization of functional and molecular indices of myocardial remodeling in a rat model. CKD was induced by a 5/6 nephrectomy in 9-week-old male and female Wistar rats. Serum and urine tests, transthoracic echocardiography, left ventricular (LV) histology, and quantitative reverse transcription polymerase chain reaction (RT-qPCR) were performed at week 8 or 9. Moreover, LV alterations were also tested in permeabilized cardiomyocytes (CMs) by force measurements and Western immunoblotting. CKD resulted in the development of a more severe uremic cardiomyopathy in male rats—including LVH, LV diastolic dysfunction, and fibrosis—than in female rats, where only LVH was observed. A uremic cardiomyopathy was also associated with a decrease in maximal Ca2+-activated force (Fmax) in CMs of male rats. Additionally, increases in CM Ca2+-independent passive stiffness (Fpassive) and decreases in cardiac myosin-binding protein C (cMyBP-C) phosphorylation levels were significantly larger in male than female rats. In conclusion, a uremic cardiomyopathy involved cardiac remodeling in both sexes. Nevertheless, male rats exhibited more pronounced signs of macroscopic and microscopic alterations than their female counterparts, illustrating a sex-dependent component of uremic cardiomyopathy. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Vágó Rebeka Rita |e aut |
| 700 | 0 | 1 | |a Nagy László |e aut |
| 700 | 0 | 1 | |a Ráduly Arnold Péter |e aut |
| 700 | 0 | 1 | |a Gulyás András |e aut |
| 700 | 0 | 1 | |a Kupecz Klaudia |e aut |
| 700 | 0 | 1 | |a Azar Lilian |e aut |
| 700 | 0 | 1 | |a Márványkövi Fanni Magdolna |e aut |
| 700 | 0 | 1 | |a Szűcs Gergő |e aut |
| 700 | 0 | 1 | |a Siska Andrea |e aut |
| 700 | 0 | 1 | |a Cserni Gábor |e aut |
| 700 | 0 | 1 | |a Földesi Imre |e aut |
| 700 | 0 | 1 | |a Papp Zoltán |e aut |
| 700 | 0 | 1 | |a Sárközy Márta |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/36221/1/ijms-26-02259.pdf |z Dokumentum-elérés |