The expression of cytokines and chemokines potentially distinguishes mild and severe psoriatic non-lesional and resolved skin from healthy skin and indicates different stages of inflammation
In the psoriatic non-lesional (PS-NL) skin, the tissue environment potentially influences the development and recurrence of lesions. Therefore, we aimed to investigate mechanisms involved in regulating tissue organization in PS-NL skin. Cytokine, chemokine, protease, and protease inhibitor levels we...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
|
| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
25 No. 20 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms252011292 |
| mtmt: | 35481281 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/35002 |
| LEADER | 02817nab a2200313 i 4500 | ||
|---|---|---|---|
| 001 | publ35002 | ||
| 005 | 20241029114137.0 | ||
| 008 | 241029s2024 hu o 000 eng d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms252011292 |2 doi | |
| 024 | 7 | |a 35481281 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bozó Renáta | |
| 245 | 1 | 4 | |a The expression of cytokines and chemokines potentially distinguishes mild and severe psoriatic non-lesional and resolved skin from healthy skin and indicates different stages of inflammation |h [elektronikus dokumentum] / |c Bozó Renáta |
| 260 | |c 2024 | ||
| 300 | |a 25 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 25 No. 20 | |
| 520 | 3 | |a In the psoriatic non-lesional (PS-NL) skin, the tissue environment potentially influences the development and recurrence of lesions. Therefore, we aimed to investigate mechanisms involved in regulating tissue organization in PS-NL skin. Cytokine, chemokine, protease, and protease inhibitor levels were compared between PS-NL skin of patients with mild and severe symptoms and healthy skin. By comparing mild and severe PS-NL vs. healthy skin, differentially expressed cytokines and chemokines suggested alterations in hemostasis-related processes, while protease inhibitors showed no psoriasis severity-related changes. Comparing severe and mild PS-NL skin revealed disease severity-related changes in the expression of proteases, cytokines, and chemokines primarily involving methyl-CpG binding protein 2 (MECP2) and extracellular matrix organization-related mechanisms. Cytokine and chemokine expression in clinically resolved versus healthy skin showed slight interleukin activity, differing from patterns in mild and severe PS-NL skin. Immunofluorescence analysis revealed the severity-dependent nuclear expression pattern of MECP2 and decreased expression of 5-methylcytosine and 5-hydroxymethylcytosine in the PS-NL vs. healthy skin, and in resolved vs. healthy skin. Our results suggest distinct cytokine-chemokine signaling between the resolved and PS-NL skin of untreated patients with varying severities. These results highlight an altered inflammatory response, epigenetic regulation, and tissue organization in different types of PS-NL skin with possibly distinct, severity-dependent para-inflammatory states. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Flink Lili Borbála |e aut |
| 700 | 0 | 1 | |a Ambrus Barbara |e aut |
| 700 | 0 | 1 | |a Ghaffarinia Ameneh |e aut |
| 700 | 0 | 1 | |a Koncz Balázs |e aut |
| 700 | 0 | 1 | |a Kui Róbert |e aut |
| 700 | 0 | 1 | |a Gyulai Rolland Péter |e aut |
| 700 | 0 | 1 | |a Kemény Lajos |e aut |
| 700 | 0 | 2 | |a Csörgő Sándorné Bata Zsuzsanna |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/35002/1/BozoR.Theexpressionofcytokines_2024_szc._IJMS.pdf |z Dokumentum-elérés |