Shotgun Analysis of Gut Microbiota with Body Composition and Lipid Characteristics in Crohn’s Disease
Alterations to intestinal microbiota are assumed to occur in the pathogenesis of inflammatory bowel disease (IBD). This study aims to analyze the association of fecal microbiota composition, body composition, and lipid characteristics in patients with Crohn’s disease (CD). In our cross-sectional stu...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
|
| Sorozat: | BIOMEDICINES
12 No. 9 |
| Tárgyszavak: | |
| doi: | 10.3390/biomedicines12092100 |
| mtmt: | 35315290 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34669 |
| LEADER | 02818nab a2200433 i 4500 | ||
|---|---|---|---|
| 001 | publ34669 | ||
| 005 | 20240918012046.0 | ||
| 008 | 240918s2024 hu o 000 eng d | ||
| 022 | |a 2227-9059 | ||
| 024 | 7 | |a 10.3390/biomedicines12092100 |2 doi | |
| 024 | 7 | |a 35315290 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bacsur Péter | |
| 245 | 1 | 0 | |a Shotgun Analysis of Gut Microbiota with Body Composition and Lipid Characteristics in Crohn’s Disease |h [elektronikus dokumentum] / |c Bacsur Péter |
| 260 | |c 2024 | ||
| 300 | |a 13 | ||
| 490 | 0 | |a BIOMEDICINES |v 12 No. 9 | |
| 520 | 3 | |a Alterations to intestinal microbiota are assumed to occur in the pathogenesis of inflammatory bowel disease (IBD). This study aims to analyze the association of fecal microbiota composition, body composition, and lipid characteristics in patients with Crohn’s disease (CD). In our cross-sectional study, patients with CD were enrolled and blood and fecal samples were collected. Clinical and endoscopic disease activity and body composition were assessed and laboratory tests were made. Fecal bacterial composition was analyzed using the shotgun method. Microbiota alterations based on obesity, lipid parameters, and disease characteristics were analyzed. In this study, 27 patients with CD were analyzed, of which 37.0% were obese based on visceral fat area (VFA). Beta diversities were higher in non-obese patients (p < 0.001), but relative abundances did not differ. C. innocuum had a higher abundance at a high cholesterol level than Bacillota (p = 0.001, p = 0.0034). Adlercreutzia, B. longum, and Blautia alterations were correlated with triglyceride levels. Higher Clostridia (p = 0.009) and B. schinkii (p = 0.032) and lower Lactobacillus (p = 0.035) were connected to high VFA. Disease activity was coupled with dysbiotic elements. Microbiota alterations in obesity highlight the importance of gut microbiota in diseases with a similar inflammatory background and project therapeutic options. | |
| 650 | 4 | |a Gasztroenterológia és hepatológia | |
| 700 | 0 | 1 | |a Resál Tamás |e aut |
| 700 | 0 | 1 | |a Farkas Bernadett |e aut |
| 700 | 0 | 1 | |a Jójárt Boldizsár |e aut |
| 700 | 0 | 1 | |a Gyuris Zoltán |e aut |
| 700 | 0 | 1 | |a Jaksa Gábor |e aut |
| 700 | 0 | 1 | |a Pintér Lajos |e aut |
| 700 | 0 | 1 | |a Takács Bertalan Vilmos |e aut |
| 700 | 0 | 1 | |a Pál Sára |e aut |
| 700 | 0 | 1 | |a Gácser Attila |e aut |
| 700 | 0 | 1 | |a Szántó Kata Judit |e aut |
| 700 | 0 | 1 | |a Rutka Mariann |e aut |
| 700 | 0 | 1 | |a Bor Renáta |e aut |
| 700 | 0 | 1 | |a Fábián Anna |e aut |
| 700 | 0 | 1 | |a Farkas Klaudia |e aut |
| 700 | 0 | 1 | |a Maléth József |e aut |
| 700 | 0 | 1 | |a Szepes Zoltán |e aut |
| 700 | 0 | 1 | |a Molnár Tamás |e aut |
| 700 | 0 | 1 | |a Bálint Anita |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/34669/1/biomedicines-12-02100.pdf |z Dokumentum-elérés |