Mutual Inhibition of Antithrombin III and SARS-CoV-2 Cellular Attachment to Syndecans Implications for COVID-19 Treatment and Vaccination /
Antithrombin III (ATIII) is a potent endogenous anticoagulant that binds to heparan sulfate proteoglycans (HSPGs) on endothelial cells' surfaces. Among these HSPGs, syndecans (SDCs) are crucial as transmembrane receptors bridging extracellular ligands with intracellular signaling pathways. Spec...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
25 No. 14 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms25147534 |
| mtmt: | 35161178 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34449 |
| LEADER | 02187nab a2200253 i 4500 | ||
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| 008 | 240827s2024 hu o 000 eng d | ||
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| 024 | 7 | |a 10.3390/ijms25147534 |2 doi | |
| 024 | 7 | |a 35161178 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hudák Anett | |
| 245 | 1 | 0 | |a Mutual Inhibition of Antithrombin III and SARS-CoV-2 Cellular Attachment to Syndecans |h [elektronikus dokumentum] : |b Implications for COVID-19 Treatment and Vaccination / |c Hudák Anett |
| 260 | |c 2024 | ||
| 300 | |a 13 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 25 No. 14 | |
| 520 | 3 | |a Antithrombin III (ATIII) is a potent endogenous anticoagulant that binds to heparan sulfate proteoglycans (HSPGs) on endothelial cells' surfaces. Among these HSPGs, syndecans (SDCs) are crucial as transmembrane receptors bridging extracellular ligands with intracellular signaling pathways. Specifically, syndecan-4 (SDC4) has been identified as a key receptor on endothelial cells for transmitting the signaling effects of ATIII. Meanwhile, SDCs have been implicated in facilitating the cellular internalization of SARS-CoV-2. Given the complex interactions between ATIII and SDC4, our study analyzed the impact of ATIII on the virus entry into host cells. While ATIII binds to all SDC isoforms, it shows the strongest affinity for SDC4. SDCs' heparan sulfate chains primarily influence ATIII's SDC attachment, although other parts might also play a role in ATIII's dominant affinity toward SDC4. ATIII significantly reduces SARS-CoV-2's cellular entry into cell lines expressing SDCs, suggesting a competitive inhibition mechanism at the SDC binding sites, particularly SDC4. Conversely, the virus or its spike protein decreases the availability of SDCs on the cell surface, reducing ATIII's cellular attachment and hence contributing to a procoagulant environment characteristic of COVID-19. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Pusztai Dávid |e aut |
| 700 | 0 | 1 | |a Letoha Annamária |e aut |
| 700 | 0 | 1 | |a Letoha Tamás |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/34449/1/Hudak.pdf |z Dokumentum-elérés |