Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant
Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points of view. The present study focused on the isolation, structure determination, and pharmacological investigation of constituents from Carex praecox. Twenty-six co...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | MOLECULES
29 No. 14 |
| Tárgyszavak: | |
| doi: | 10.3390/molecules29143427 |
| mtmt: | 35156158 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34410 |
| LEADER | 02143nab a2200313 i 4500 | ||
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| 001 | publ34410 | ||
| 005 | 20240802093326.0 | ||
| 008 | 240802s2024 hu o 000 eng d | ||
| 022 | |a 1420-3049 | ||
| 024 | 7 | |a 10.3390/molecules29143427 |2 doi | |
| 024 | 7 | |a 35156158 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dávid Csilla Zsuzsanna | |
| 245 | 1 | 0 | |a Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant |h [elektronikus dokumentum] / |c Dávid Csilla Zsuzsanna |
| 260 | |c 2024 | ||
| 300 | |a 19 | ||
| 490 | 0 | |a MOLECULES |v 29 No. 14 | |
| 520 | 3 | |a Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points of view. The present study focused on the isolation, structure determination, and pharmacological investigation of constituents from Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, and phenylpropanoids, were identified from the methanol extract of the plant. Five of these compounds, namely, carexines A–E, are previously undescribed natural products. All compounds were isolated for the first time from C. praecox. The ACE-inhibitory activity of seven stilbenoid compounds was tested, and (–)-hopeaphenol proved to be the most active (IC50 7.7 ± 0.9 μM). The enzyme–kinetic studies revealed a mixed-type inhibition; therefore, domain-specific studies were also conducted. The in silico docking of (–)-hopeaphenol to the ACE affirmed some favorable interactions. In addition, the antiproliferative and antibacterial effects of some compounds were also evaluated. | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Kúsz Norbert |e aut |
| 700 | 0 | 1 | |a Agbadua Orinamhe Godwin |e aut |
| 700 | 0 | 1 | |a Berkecz Róbert |e aut |
| 700 | 0 | 1 | |a Kincses Annamária |e aut |
| 700 | 0 | 1 | |a Spengler Gabriella |e aut |
| 700 | 0 | 1 | |a Hunyadi Attila |e aut |
| 700 | 0 | 1 | |a Hohmann Judit |e aut |
| 700 | 0 | 1 | |a Vasas Andrea |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/34410/1/molecules-29-03427.pdf |z Dokumentum-elérés |