Effects of side chain amino nitrogen donor atoms on metal complexation of aminohydroxamic acids New diamino-hydroxamates chelating Ni(II) more strongly than Fe(III) /
Complexes of diaminohydroxamic acids 2,6-diamino-N-hydroxyhexanamide (lysinehydroxamic acid, Lysha), 2,4-diamino-N-hydroxybutanamide (2,4-diaminobutyrohydroxamic acid, Dambha) and 2,3-diamino-N-hydroxypropanamide (2,3-diaminopropionohydroxamic acid, Dampha) with manganese(II), cobalt(II), iron(II),...
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| Format: | Article |
| Published: |
2002
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| Series: | JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
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| Subjects: | |
| doi: | 10.1039/b111184a |
| mtmt: | 1377873 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34376 |
| Summary: | Complexes of diaminohydroxamic acids 2,6-diamino-N-hydroxyhexanamide (lysinehydroxamic acid, Lysha), 2,4-diamino-N-hydroxybutanamide (2,4-diaminobutyrohydroxamic acid, Dambha) and 2,3-diamino-N-hydroxypropanamide (2,3-diaminopropionohydroxamic acid, Dampha) with manganese(II), cobalt(II), iron(II), nickel(II), copper(II), zinc(II), iron(III), aluminium(III) and molybdenum(VI) in aqueous solution were studied by pH-potentiometric, UV-visible spectrophotometric and EPR methods. The two latter diaminohydroxamic acids were synthesised as new ligands and characterised. The results were compared to those of a simple alpha-amino acid derivative, alpha-alaninehydroxamic acid (alpha-Alaha) and the effects of the side chain amino group on the co-ordination mode and on the stability of the complexes formed were evaluated. As expected, the side chain amino nitrogen atom of Lysha does not co-ordinate to any of the studied metals but remains free for possible further interactions. The amino groups do not co-ordinate to aluminium(III) or iron(III) at all and the closer the side chain amino group is situated to the alpha-aminohydroxamic residue the less stable the hydroxamate complex formed in the order of Lysha, Dambha, Dampha, and hydrolytic processes become increasingly dominant. The co-ordination of the side chain amino nitrogen of Dampha and Dambha to nickel(II) and copper(II) was unambiguously observed. |
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| Physical Description: | 2632-2640 |
| ISSN: | 1472-7773 |