Three-Dimensional Speckle-Tracking Echocardiography-Derived Tricuspid Annular Properties in Acromegaly—Results from the MAGYAR-Path Study
Introduction. Acromegaly is an endocrine pathology characterized by the overproduction of human growth hormone. The present study aimed to analyze three-dimensional speckle-tracking echocardiography (3DSTE)-derived tricuspid annular (TA) properties in detail in patients with acromegaly and to compar...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | BIOMEDICINES
12 No. 7 |
| Tárgyszavak: | |
| doi: | 10.3390/biomedicines12071464 |
| mtmt: | 35085699 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/33995 |
| LEADER | 03130nab a2200289 i 4500 | ||
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| 024 | 7 | |a 10.3390/biomedicines12071464 |2 doi | |
| 024 | 7 | |a 35085699 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Nemes Attila | |
| 245 | 1 | 0 | |a Three-Dimensional Speckle-Tracking Echocardiography-Derived Tricuspid Annular Properties in Acromegaly—Results from the MAGYAR-Path Study |h [elektronikus dokumentum] / |c Nemes Attila |
| 260 | |c 2024 | ||
| 300 | |a 11 | ||
| 490 | 0 | |a BIOMEDICINES |v 12 No. 7 | |
| 520 | 3 | |a Introduction. Acromegaly is an endocrine pathology characterized by the overproduction of human growth hormone. The present study aimed to analyze three-dimensional speckle-tracking echocardiography (3DSTE)-derived tricuspid annular (TA) properties in detail in patients with acromegaly and to compare the findings to those of matched healthy controls. Methods. The present study consisted of 29 patients with acromegaly (mean age: 55.9 ± 14.5 years, 21 males), of which 13 had an active disease. The control population comprised 57 healthy subjects (mean age: 53.2 ± 8.4 years, 38 males). Results. In the presence of acromegaly, left atrial and end-diastolic left ventricular (LV) sizes were dilated, and LV ejection fraction was increased, which was accompanied by thickened interventricular septum and LV posterior wall as compared with matched healthy controls. The presence of grade 1 mitral (MR) and tricuspid (TR) regurgitations were more frequent in acromegaly than in controls, regardless of disease activity. Higher than grade 1 MR/TR was uncommon in acromegaly. The 3DSTE-derived all end-diastolic (2.47 ± 0.27 cm vs. 2.23 ± 0.27 cm; 8.73 ± 1.77 cm2 vs. 6.67 ± 1.40 cm2; 11.56 ± 1.34 cm vs. 10.20 ± 1.10 cm, p < 0.001 for all) and end-systolic (1.97 ± 0.27 cm vs. 1.77 ± 0.28 cm; 6.24 ± 1.61 cm2 vs. 5.01 ± 1.42 cm2; 9.80 ± 1.35 cm vs. 8.72 ± 1.10 cm, p < 0.001 for all) TA diameters, areas, and perimeters proved to be dilated, while TA functional parameters including TA fractional area change (28.77 ± 9.80% vs. 27.64 ± 15.34%, p = 0.720) and fractional shortening (20.60 ± 9.08% vs. 20.51 ± 8.81%, p = 0.822) were normal in acromegaly regardless of whether acromegaly was active or not. RA volumes respecting the cardiac cycle were dilated in acromegaly as compared with those of healthy controls regardless of disease activity and were associated with respective changes in TA dimensions. Conclusions. In the presented acromegaly patients, significant TA dilation with preserved function could be detected regardless of disease activity. RA volumes and TA dimensions are correlated in acromegaly. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Rácz Gergely |e aut |
| 700 | 0 | 1 | |a Kormányos Árpád |e aut |
| 700 | 0 | 1 | |a Gyenes Nándor |e aut |
| 700 | 0 | 1 | |a Ambrus Nóra |e aut |
| 700 | 0 | 1 | |a Lengyel Csaba Attila |e aut |
| 700 | 0 | 1 | |a Valkusz Zsuzsanna |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/33995/1/NemesBiomedicines2024.pdf |z Dokumentum-elérés |