02506nab a2200361 i 4500 publ33461 20250416151738.0 240624s2025 hu o 000 eng d 0945-6317 10.1007/s00428-024-03852-2 doi 35061763 mtmt SZTE Publicatio Repozitórium hun eng Pancsa Tamás TRPS1 expression in breast angiosarcoma [elektronikus dokumentum] / Pancsa Tamás 2025 479-490 VIRCHOWS ARCHIV 486 No. 3 Angiosarcoma (AS) of the breast, a rare mesenchymal neoplasm, exhibits distinct forms based on etiological and genetic features. While cases with typical clinical presentation and morphology allow for a straightforward diagnosis, challenges arise when clinical data are scarce, diagnostic material is limited, or morphological characteristics overlap with other tumors, including undifferentiated carcinomas. The trichorhinophalangeal syndrome protein 1 (TRPS1), once regarded as highly specific for breast carcinomas, now faces doubts regarding its reliability. This study explores TRPS1 expression in breast AS. Our investigation revealed that 60% of AS cases displayed TRPS1 labeling, contrasting with the 40% lacking expression. Scoring by four independent readers established a consensus, designating 12/35 ASs as unequivocally TRPS1-positive. However, uncertainty surrounded nine further cases due to a lack of reader agreement (being substantial as reflected by a kappa value of 0.76). These findings challenge the perceived specificity of TRPS1, shedding light on its presence in a noteworthy proportion of breast ASs. Consequently, the study underscores the importance of a comprehensive approach in evaluating breast ASs and expands the range of entities within the differential diagnosis associated with TRPS1 labeling. Általános orvostudomány Pósfai Boglárka aut Schubert Anna aut Almási Szintia aut Papp Eszter aut Chang Chien Yi-Che aut Kálmán Endre aut Kovács Attila aut Kulka Janina aut Varga Linda aut Cserni Gábor aut Kuthi Levente aut http://publicatio.bibl.u-szeged.hu/33461/7/35061763.pdf Dokumentum-elérés http://publicatio.bibl.u-szeged.hu/33461/1/s00428-024-03852-2.pdf Dokumentum-elérés