Capsaicin-induced excitation of locus coeruleus neurons
The noradrenergic pontine nucleus locus coeruleus (LC) seems to be involved in sensory processing. In the present study, the effect of capsaicin, a drug which specifically interferes with chemosensitive primary afferents, on LC firing rate was analysed, utilizing electrophysiological techniques. In...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1987
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| Sorozat: | ACTA PHYSIOLOGICA SCANDINAVICA
129 No. 3 |
| Tárgyszavak: | |
| doi: | 10.1111/j.1748-1716.1987.tb08086.x |
| mtmt: | 1339567 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32978 |
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| 008 | 250428s1987 hu o 000 eng d | ||
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| 024 | 7 | |a 10.1111/j.1748-1716.1987.tb08086.x |2 doi | |
| 024 | 7 | |a 1339567 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hajos M. | |
| 245 | 1 | 0 | |a Capsaicin-induced excitation of locus coeruleus neurons |h [elektronikus dokumentum] / |c Hajos M. |
| 260 | |c 1987 | ||
| 300 | |a 415-420 | ||
| 490 | 0 | |a ACTA PHYSIOLOGICA SCANDINAVICA |v 129 No. 3 | |
| 520 | 3 | |a The noradrenergic pontine nucleus locus coeruleus (LC) seems to be involved in sensory processing. In the present study, the effect of capsaicin, a drug which specifically interferes with chemosensitive primary afferents, on LC firing rate was analysed, utilizing electrophysiological techniques. In control rats, low doses of capsaicin (1-8 micrograms kg-1 i.v.) caused a marked excitation of LC units. The effect was instantaneous in onset but short-lasting and no signs of tachyphylaxis were observed. The excitation was maintained in adult rats treated as neonates with high doses of capsaicin (50 mg kg-1 s.c.) but almost totally prevented by pretreatment of adult rats with high doses of capsaicin (300 mg kg-1 s.c.). According to our histological data, using selective silver impregnation techniques, the LC seems not to receive innervation by sensory primary afferents. It is proposed that the capsaicin-induced excitation of LC neurons is a centrally mediated effect and might, in part, be involved in the analgetic effect induced by the drug. | |
| 650 | 4 | |a Biológiai tudományok | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Jancsó Gábor |e aut |
| 700 | 0 | 1 | |a Engberg G. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/32978/1/aok_klny_411_87.pdf |z Dokumentum-elérés |