In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers
Some of the phenothiazines and dibenz[b,flazepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leuk...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | ANTICANCER RESEARCH
12 No. 1 |
| Tárgyszavak: | |
| mtmt: | 1791859 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32259 |
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| 024 | 7 | |a 1791859 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Molnár József | |
| 245 | 1 | 3 | |a In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers |h [elektronikus dokumentum] / |c Molnár József |
| 260 | |c 1992 | ||
| 300 | |a 273-280 | ||
| 490 | 0 | |a ANTICANCER RESEARCH |v 12 No. 1 | |
| 520 | 3 | |a Some of the phenothiazines and dibenz[b,flazepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leukocytes. The superoxide dismutase inhibition by 7,8-dioxochlorpromazine and 6,9-dioxochlorpromazine have some relation to the growth inhibitory action on the growth of HEP-2 and prolactinoma cells in vitro. The antiproliferative effects of phenothiazines were synergized with resistance modifers like verapamil, omeprazole and tubulozole-C, due to increased drug-influx or decreased drug-efflux and due to possible action on the cytoskeleton. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Tarodi B |e aut |
| 700 | 0 | 1 | |a Gálfi Márta |e aut |
| 700 | 0 | 1 | |a Matkovics B |e aut |
| 700 | 0 | 1 | |a Motohashi Noboru |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/32259/1/aok_klny_588_92.pdf |z Dokumentum-elérés |