Immunotoxic effects of MPT-IP containing 60% methylparathion in mice
The effects of a single large and repeated small doses of MPT-IP (the industrial product used to produce Wofatox EC 50) containing 60% methylparathion, on the humoral and cellular immunoreactivity of CFLP mice were investigated. Administration of a single LD50/2 dose 3 d prior to immunization caused...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | HUMAN & EXPERIMENTAL TOXICOLOGY
11 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1177/096032719201100102 |
| mtmt: | 2139152 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32240 |
| LEADER | 01730nab a2200253 i 4500 | ||
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| 008 | 250401s1992 hu o 000 eng d | ||
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| 024 | 7 | |a 10.1177/096032719201100102 |2 doi | |
| 024 | 7 | |a 2139152 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Institóris László | |
| 245 | 1 | 0 | |a Immunotoxic effects of MPT-IP containing 60% methylparathion in mice |h [elektronikus dokumentum] / |c Institóris László |
| 260 | |c 1992 | ||
| 300 | |a 11-16 | ||
| 490 | 0 | |a HUMAN & EXPERIMENTAL TOXICOLOGY |v 11 No. 1 | |
| 520 | 3 | |a The effects of a single large and repeated small doses of MPT-IP (the industrial product used to produce Wofatox EC 50) containing 60% methylparathion, on the humoral and cellular immunoreactivity of CFLP mice were investigated. Administration of a single LD50/2 dose 3 d prior to immunization caused a 40% increase in the number of splenic PFC on the 5th day but no significant increase in serum antibody titre on the 7th day after immunization. Treatment for 4 weeks with an LD50/40 dose resulted in a 100% increase in splenic PFC, also not associated with a change in serum antibody titre. Under the same conditions and LD50/20 dose had no effect on these parameters. Neither the single large nor the repeated small doses had any effect on the intensity or time course of a DTH reaction. The results show that MPT-IP has an immunotoxic potential in mice under certain experimental conditions. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Siroki Olga |e aut |
| 700 | 0 | 1 | |a Tóth Szabolcs |e aut |
| 700 | 0 | 1 | |a Dési Illés |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/32240/1/aok_klny_352_92.pdf |z Dokumentum-elérés |