02607nab a2200325 i 4500 publ31872 20240524081650.0 240524s2024 hu o 000 eng d 2072-6694 10.3390/cancers16091745 doi 34825468 mtmt SZTE Publicatio Repozitórium hun eng Abonyi-Tóth Zsolt Incident Cancer Risk in Patients with Incident Type 2 Diabetes Mellitus in Hungary (Part 1) [elektronikus dokumentum] / Abonyi-Tóth Zsolt 2024 14 CANCERS 16 No. 9 Abstract (1) Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cancer but how these two diseases associate is still debated. The goal of this study was the assessment of the overall incidence of cancer among patients with newly diagnosed T2DM in Hungary. (2) Methods: A nationwide, retrospective, longitudinal study was performed using a Hungarian database. After exclusion of cases of age < 18 years, with gestational diabetes, with polycystic ovary syndrome, and with type 1 and prevalent type 2 diabetes mellitus, the incident T2DM (approx. 50,000 cases yearly) and for comparison, the diabetes-free Hungarian adult population (approx. 7,000,000 cases yearly) was included in the study. The primary endpoints were the overall and site-specific incidence and annual percentage change of the incidence of cancer in both populations. (3) Results: The overall incidence of cancer in patients amounted to 29.4/1000 and 6.6/1000 with or without T2DM, respectively, and the OR (95%CI) of cancer of the T2DM group was 4.32 (4.14–4.53), p < 0.0001. The risk of having cancer was age dependent. The incidence of cancer was declining in the non-diabetic but was unchanged in the T2DM population. The average lag time of diagnosing cancer after the detection of T2DM was 3.86 months. (4) Conclusions: Incident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months. Klinikai orvostan Rokszin György Aurél aut Bajcsayné Fábián Ibolya aut Kiss Zoltán aut Jermendy György aut Kempler Péter aut Lengyel Csaba Attila aut Wittmann István aut Molnár Gergő Attila aut Sütő Gábor aut http://publicatio.bibl.u-szeged.hu/31872/1/Abonyi.pdf Dokumentum-elérés