Kemoterápiás szer rektális alkalmazásának tapasztalatai 1. rész. In vitro biofarmáciai vizsgálatok; optimális vehikulum kiválasztása /
The factors influencing in vitro liberation (Part 1) and in vivo absorption (Part 2)from trimethoprim-containing rectal suppositories and the authors' results related to them are reported in this two-part publication. Special emphasis was laid on selecting the optimal suppository base which is...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1998
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| Sorozat: | ACTA PHARMACEUTICA HUNGARICA
68 No. 4 |
| Tárgyszavak: | |
| mtmt: | 1767246 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/31623 |
| Tartalmi kivonat: | The factors influencing in vitro liberation (Part 1) and in vivo absorption (Part 2)from trimethoprim-containing rectal suppositories and the authors' results related to them are reported in this two-part publication. Special emphasis was laid on selecting the optimal suppository base which is harmless physiologically yet not indifferent pharmacologically. From among the 24 compositions studied, a lipophilic mixture containing a surface active additive (Witepsol W 35) and a hydrophilic (Macrogolum) mixture were found to be the best in all respects. Liberation from the trimethoprim-containing rectal suppositories was measured with in vitro dynamic diffusion and spectrophotometrically. A power relation was found to exist between the quantity of the released pharmacon and the diffusion time, and a significant negative exponential relation was observed between the doses and their respective in vitro availability values. |
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| Terjedelem/Fizikai jellemzők: | 224-228 |
| ISSN: | 0001-6659 |