Nifluminsav oldékonysági tulajdonságainak növelése ciklodextrin és polividon felhasználásával
One of the most important task of the pharmaceutical technology is to reach a possible high gastrointestinal absorbtion of the active ingredient. Therefore, it is necessary to have a good solubility in the gastric/intestinal medium. In this way the applied drug quantity and unwanted side effects can...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2005
|
| Sorozat: | ACTA PHARMACEUTICA HUNGARICA
75 No. 1 |
| Tárgyszavak: | |
| mtmt: | 1912742 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/30771 |
| LEADER | 02090nab a2200241 i 4500 | ||
|---|---|---|---|
| 001 | publ30771 | ||
| 005 | 20241029124754.0 | ||
| 008 | 241018s2005 hu o 000 hun d | ||
| 022 | |a 0001-6659; 1587-1495 | ||
| 024 | 7 | |a 1912742 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a hun | ||
| 100 | 1 | |a Ambrus Rita | |
| 245 | 1 | 0 | |a Nifluminsav oldékonysági tulajdonságainak növelése ciklodextrin és polividon felhasználásával |h [elektronikus dokumentum] / |c Ambrus Rita |
| 260 | |c 2005 | ||
| 300 | |a 31-36 | ||
| 490 | 0 | |a ACTA PHARMACEUTICA HUNGARICA |v 75 No. 1 | |
| 520 | 3 | |a One of the most important task of the pharmaceutical technology is to reach a possible high gastrointestinal absorbtion of the active ingredient. Therefore, it is necessary to have a good solubility in the gastric/intestinal medium. In this way the applied drug quantity and unwanted side effects can be reduced with solubility increasing. The water-insoluble drug's solubility and bioavailability can be increased by the alteration of their physicochemical properties. Nifluminic acid is a frequently used anti-inflammatory drug with low aqueous solubility. Inclusion complexation with cyclodextrins is an efficacious method to improve the solubility, stability and bioavailability. Ternary systems were prepared and investigated to use nifluminic acid, hydoxypropyl-β-cyclodextrin and polyvidone. The aims of the study were to investigate the solubility rate, the in vitro diffusion ability, to determine the n-octanol/water partition coefficient, and to study the thermoanalitycal properties of products. The results suggested that complexation with cyclodextrin and the use of polyvidone is better method than to prepare binary systems. Inclusion complexation was presumed in the event of the ternary composition to improve the bioavailability of nifluminic acid. | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Kata Mihály |e aut |
| 700 | 0 | 1 | |a Erős István |e aut |
| 700 | 0 | 1 | |a Aigner Zoltán |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/30771/1/aok_klny_394_05.pdf |z Dokumentum-elérés |