Childhood-onset depression and arterial stiffness in young adulthood
Objectives: The literature on childhood-onset depression and future compromised vascular function is suggestive but limited. The objective of this study was to determine if arterial stiffness, a predictor of future cardiovascular disease (CVD), measured in young adulthood, is associated with childho...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2021
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| Sorozat: | JOURNAL OF PSYCHOSOMATIC RESEARCH
148 |
| Tárgyszavak: | |
| doi: | 10.1016/j.jpsychores.2021.110551 |
| mtmt: | 32099487 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/30105 |
| LEADER | 03022nab a2200325 i 4500 | ||
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| 005 | 20240412091525.0 | ||
| 008 | 240412s2021 hu o 0|| eng d | ||
| 022 | |a 0022-3999 | ||
| 024 | 7 | |a 10.1016/j.jpsychores.2021.110551 |2 doi | |
| 024 | 7 | |a 32099487 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 2 | |a Barinas-Mitchell Emma | |
| 245 | 1 | 0 | |a Childhood-onset depression and arterial stiffness in young adulthood |h [elektronikus dokumentum] / |c Barinas-Mitchell Emma |
| 260 | |c 2021 | ||
| 300 | |a 6 | ||
| 490 | 0 | |a JOURNAL OF PSYCHOSOMATIC RESEARCH |v 148 | |
| 520 | 3 | |a Objectives: The literature on childhood-onset depression and future compromised vascular function is suggestive but limited. The objective of this study was to determine if arterial stiffness, a predictor of future cardiovascular disease (CVD), measured in young adulthood, is associated with childhood-onset depression. Methods: Cardiometabolic risk factors and pulse wave velocity (PWV), a measure of arterial stiffness, were cross-sectionally assessed in young adults with a history of childhood-onset depression (clinical diagnosis of major depressive episode or dysthymic disorder; N = 294 probands; initially recruited via child mental health facilities across Hungary; mean age of first depressive episode = 10.4 years), their never-depressed full biological siblings (N = 269), and never-depressed controls (N = 169). The mean ages of probands, siblings, and controls at the PWV visit were 25.6, 25.0, and 21.7 years, respectively, and 8.8% of the probands were in a current depressive episode. Results: Controlling for age, sex, age*sex, education, and family clusters, PWV (m/s) did not statistically differ across the groups (probands = 7.01; siblings = 6.98; controls = 6.81). However, after adjusting for key covariates, there were several across-group differences in CVD risk factors: compared to controls, probands and siblings had higher diastolic blood pressure and lower high-density lipoprotein cholesterol, probands had higher triglycerides, and siblings had higher body mass index (all p < 0.05). Conclusion: We found limited evidence of an association between a history of childhood-onset depression and young adulthood arterial stiffness. However, our findings of elevated cardiovascular risk factors in those with childhood-onset depression suggest that pediatric depression may predispose to increased CVD risk later in life and warrants further investigation. © 2021 Elsevier Inc. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Yang Xiao |e aut |
| 700 | 0 | 1 | |a Matthews Karen A. |e aut |
| 700 | 0 | 1 | |a Columbus Mindy L. |e aut |
| 700 | 0 | 1 | |a George Charles J. |e aut |
| 700 | 0 | 1 | |a Dósa Edit |e aut |
| 700 | 0 | 1 | |a Kiss Enikő |e aut |
| 700 | 0 | 1 | |a Kapornai Krisztina |e aut |
| 700 | 0 | 1 | |a Evans Rhobert |e aut |
| 700 | 0 | 1 | |a Kovacs Maria |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/30105/1/BarinasHuCardioChildhoodDepressionandarterialstiffnessinyoungadulthood2021.pdf |z Dokumentum-elérés |