Hemoadsorption in the critically ill-Final results of the International CytoSorb Registry

The aim of the current paper is to summarize the results of the International CytoSorb Registry. Data were collected on patients of the intensive care unit. The primary endpoint was actual in-hospital mortality compared to the mortality predicted by APACHE II score. The main secondary endpoints were...

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Bibliographic Details
Main Authors: Hawchar Fatime
Tomescu Dana
Träger Karl
Joskowiak Dominik
Kogelmann Klaus
Soukup Jens
Friesecke Singrun
Jacob David
Gummert Jan
Faltlhauser Andreas
Aucella Filippo
van Tellingen Martijn
Malbrain Manu L N G
Bogdanski Ralph
Weiss Günter
Herbrich Andreas
Utzolino Stefan
Nierhaus Axel
Baumann Andreas
Hartjes Andreas
Henzler Dietrich
Grigoryev Evgeny
Fritz Harald
Bach Friedhelm
Schröder Stefan
Weyland Andreas
Gottschaldt Udo
Menzel Matthias
Zachariae Olivier
Novak Radovan
Molnár Zsolt
et al
Format: Article
Published: 2022
Series:PLOS ONE 17 No. 10
Subjects:
doi:10.1371/journal.pone.0274315

mtmt:33202706
Online Access:http://publicatio.bibl.u-szeged.hu/30053
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245 1 0 |a Hemoadsorption in the critically ill-Final results of the International CytoSorb Registry  |h [elektronikus dokumentum] /  |c  Hawchar Fatime 
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520 3 |a The aim of the current paper is to summarize the results of the International CytoSorb Registry. Data were collected on patients of the intensive care unit. The primary endpoint was actual in-hospital mortality compared to the mortality predicted by APACHE II score. The main secondary endpoints were SOFA scores, inflammatory biomarkers and overall evaluation of the general condition. 1434 patients were enrolled. Indications for hemoadsorption were sepsis/septic shock (N = 936); cardiac surgery perioperatively (N = 172); cardiac surgery postoperatively (N = 67) and "other" reasons (N = 259). APACHE-II-predicted mortality was 62.0±24.8%, whereas observed hospital mortality was 50.1%. Overall SOFA scores did not change but cardiovascular and pulmonary SOFA scores decreased by 0.4 [-0.5;-0.3] and -0.2 [-0.3;-0.2] points, respectively. Serum procalcitonin and C-reactive protein levels showed significant reduction: -15.4 [-19.6;-11.17] ng/mL; -17,52 [-70;44] mg/L, respectively. In the septic cohort PCT and IL-6 also showed significant reduction: -18.2 [-23.6;-12.8] ng/mL; -2.6 [-3.0;-2.2] pg/mL, respectively. Evaluation of the overall effect: minimal improvement (22%), much improvement (22%) and very much improvement (10%), no change observed (30%) and deterioration (4%). There was no significant difference in the primary outcome of mortality, but there were improvements in cardiovascular and pulmonary SOFA scores and a reduction in PCT, CRP and IL-6 levels. Trial registration: ClinicalTrials.gov Identifier: NCT02312024 (retrospectively registered). 
650 4 |a Klinikai orvostan 
700 0 1 |a Tomescu Dana  |e aut 
700 0 1 |a Träger Karl  |e aut 
700 0 1 |a Joskowiak Dominik  |e aut 
700 0 1 |a Kogelmann Klaus  |e aut 
700 0 1 |a Soukup Jens  |e aut 
700 0 1 |a Friesecke Singrun  |e aut 
700 0 1 |a Jacob David  |e aut 
700 0 1 |a Gummert Jan  |e aut 
700 0 1 |a Faltlhauser Andreas  |e aut 
700 0 1 |a Aucella Filippo  |e aut 
700 0 2 |a van Tellingen Martijn  |e aut 
700 0 2 |a Malbrain Manu L N G  |e aut 
700 0 2 |a Bogdanski Ralph  |e aut 
700 0 2 |a Weiss Günter  |e aut 
700 0 2 |a Herbrich Andreas  |e aut 
700 0 2 |a Utzolino Stefan  |e aut 
700 0 2 |a Nierhaus Axel  |e aut 
700 0 2 |a Baumann Andreas  |e aut 
700 0 2 |a Hartjes Andreas  |e aut 
700 0 2 |a Henzler Dietrich  |e aut 
700 0 2 |a Grigoryev Evgeny  |e aut 
700 0 2 |a Fritz Harald  |e aut 
700 0 2 |a Bach Friedhelm  |e aut 
700 0 2 |a Schröder Stefan  |e aut 
700 0 2 |a Weyland Andreas  |e aut 
700 0 2 |a Gottschaldt Udo  |e aut 
700 0 2 |a Menzel Matthias  |e aut 
700 0 2 |a Zachariae Olivier  |e aut 
700 0 2 |a Novak Radovan  |e aut 
700 0 2 |a Molnár Zsolt  |e aut 
700 0 2 |a et al.  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/30053/1/33202706_journal.pone.0274315.pdf  |z Dokumentum-elérés