Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin
ObjectivesTo histologically evaluate the effects of a novel human recombinant amelogenin (rAmelX) on periodontal wound healing / regeneration in recession-type defects.Materials and methodsA total of 17 gingival recession-type defects were surgically created in the maxilla of three minipigs. The def...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | CLINICAL ORAL INVESTIGATIONS
27 No. 9 |
| Tárgyszavak: | |
| doi: | 10.1007/s00784-023-05123-x |
| mtmt: | 34196835 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/29374 |
| LEADER | 02277nab a2200289 i 4500 | ||
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| 001 | publ29374 | ||
| 005 | 20240123084544.0 | ||
| 008 | 240123s2023 hu o 000 Angol d | ||
| 022 | |a 1432-6981 | ||
| 024 | 7 | |a 10.1007/s00784-023-05123-x |2 doi | |
| 024 | 7 | |a 34196835 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Chackartchi Tali | |
| 245 | 1 | 0 | |a Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin |h [elektronikus dokumentum] / |c Chackartchi Tali |
| 260 | |c 2023 | ||
| 300 | |a 5041-5048 | ||
| 490 | 0 | |a CLINICAL ORAL INVESTIGATIONS |v 27 No. 9 | |
| 520 | 3 | |a ObjectivesTo histologically evaluate the effects of a novel human recombinant amelogenin (rAmelX) on periodontal wound healing / regeneration in recession-type defects.Materials and methodsA total of 17 gingival recession-type defects were surgically created in the maxilla of three minipigs. The defects were randomly treated with a coronally advanced flap (CAF) and either rAmelX (test), or a CAF and placebo (control). At three months following reconstructive surgery, the animals were euthanized, and the healing outcomes histologically evaluated.ResultsThe test group yielded statistically significantly (p = 0.047) greater formation of cementum with inserting collagen fibers compared with the control group (i.e., 4.38 mm & PLUSMN; 0.36 mm vs. 3.48 mm & PLUSMN; 1.13 mm). Bone formation measured 2.15 mm & PLUSMN; 0.8 mm in the test group and 2.24 mm & PLUSMN; 1.23 mm in the control group, respectively, without a statistically significant difference (p = 0.94).ConclusionsThe present data have provided for the first-time evidence for the potential of rAmelX to promote regeneration of periodontal ligament and root cementum in recession-type defects, thus warranting further preclinical and clinical testing. | |
| 650 | 4 | |a Fogászat, szájsebészet és -gyógyászat | |
| 700 | 0 | 1 | |a Bosshardt Dieter D. |e aut |
| 700 | 0 | 1 | |a Imber Jean-Claude |e aut |
| 700 | 0 | 1 | |a Staehli Alexandra |e aut |
| 700 | 0 | 1 | |a Sacks Hagit |e aut |
| 700 | 0 | 1 | |a Nagy Katalin |e aut |
| 700 | 0 | 1 | |a Sculean Anton |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/29374/1/34196835s00784-023-05123-x.pdf |z Dokumentum-elérés |