Inflammatory- and immune responses in relation to bacterial replication in mice following re-infections with Chlamydophila pneumoniae
Objective: Investigation of chronic infections with Chlamydophila pneumoniae. Methods: BALB/c mice were repeatedly infected with C. pneumoniae and tested during a 1-year period. Production of histamine, IFN-γ, IL-6 and antibodies was monitored by ELISA. Live bacteria were cultured and DNA was detect...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2008
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| Sorozat: | INFLAMMATION RESEARCH
57 No. 6 |
| Tárgyszavak: | |
| doi: | 10.1007/s00011-007-7124-0 |
| mtmt: | 1158668 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/28608 |
| LEADER | 02186nab a2200313 i 4500 | ||
|---|---|---|---|
| 001 | publ28608 | ||
| 005 | 20231108131150.0 | ||
| 008 | 231108s2008 hu o 0|| Angol d | ||
| 022 | |a 1023-3830 | ||
| 024 | 7 | |a 10.1007/s00011-007-7124-0 |2 doi | |
| 024 | 7 | |a 1158668 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Kis Zoltán | |
| 245 | 1 | 0 | |a Inflammatory- and immune responses in relation to bacterial replication in mice following re-infections with Chlamydophila pneumoniae |h [elektronikus dokumentum] / |c Kis Zoltán |
| 260 | |c 2008 | ||
| 300 | |a 287-295 | ||
| 490 | 0 | |a INFLAMMATION RESEARCH |v 57 No. 6 | |
| 520 | 3 | |a Objective: Investigation of chronic infections with Chlamydophila pneumoniae. Methods: BALB/c mice were repeatedly infected with C. pneumoniae and tested during a 1-year period. Production of histamine, IFN-γ, IL-6 and antibodies was monitored by ELISA. Live bacteria were cultured and DNA was detected by PCR. Cellular immunity was tested by ELISPOT. Results: After re-infections, culture positivity and persistence of DNA in lungs and blood were shorter. Detection of DNA at late time points indicated persistent infection in a few mice. Histamine was produced after primary and re-infections, and the level correlated with the number of viable bacteria in lung. IFN-γ, IL-6 levels, IgG2/IgG1 ratio, IgA titres, and level of chlamydial heat-shock protein antibodies were higher after re-infections. IgM antibodies were demonstrated even after re-infections. High number of IFN-γ-producing splenocytes was observed after the third inoculation. Conclusion: These results promote an understanding of the patho- and immune mechanisms after C. pneumoniae re-infections. © 2008 Birkhäuser Verlag, Basel. | |
| 650 | 4 | |a Biológiai tudományok | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Burián Katalin |e aut |
| 700 | 0 | 1 | |a Tresó Bálint |e aut |
| 700 | 0 | 1 | |a Ács Katalin |e aut |
| 700 | 0 | 1 | |a Prohászka Zoltán |e aut |
| 700 | 0 | 1 | |a Füst György |e aut |
| 700 | 0 | 1 | |a Gönczöl Éva |e aut |
| 700 | 0 | 1 | |a Endrész Valéria |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/28608/1/1158668_INFLAM_RES.pdf |z Dokumentum-elérés |