02762nab a2200385 i 4500 publ28568 20231106094503.0 231106s2023 hu o 0|| Angol d 2045-2322 10.1038/s41598-023-44103-9 doi 34199654 mtmt SZTE Publicatio Repozitórium hun Angol Váradi Melinda Efficacy of immune checkpoint inhibitor therapy for advanced urothelial carcinoma in real-life clinical practice [elektronikus dokumentum] : results of a multicentric, retrospective study / Váradi Melinda 2023 11 SCIENTIFIC REPORTS 13 No. 1 Clinical trials revealed significant antitumor activity for immune checkpoint inhibitors (ICI) in metastatic urothelial carcinoma (mUC). Due to their strict eligibility criteria, clinical trials include selected patient cohorts, and thus do not necessarily represent real-world population outcomes. In this multicentric, retrospective study, we investigated real-world data to assess the effectiveness of pembrolizumab and atezolizumab and to evaluate the prognostic value of routinely available clinicopathological and laboratory parameters. Clinical and follow-up data from mUC patients who received ICIs (01/2017-12/2021) were evaluated. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and duration of response (DOR) were used as endpoints. Patients' (n = 210, n = 76 atezolizumab and 134 pembrolizumab) median OS and PFS were 13.6 and 5.9 months, respectively. Impaired ECOG-PS, the presence of visceral, liver or bone metastases, and hemoglobin levels were independently associated with poor OS and DCR. Furthermore, Bellmunt risk factors and the enhanced Bellmunt-CRP score were shown to be prognostic for OS, PFS and DCR. In conclusion, ICIs are effective treatments for a broad range of mUC patients. Our results confirmed the prognostic value of numerous risk factors and showed that Bellmunt risk scores can further be improved when adding CRP to the model. Klinikai orvostan Kordáné Horváth Orsolya aut Módos Orsolya aut Fazekas Tamás aut Grunewald Camilla M aut Niegisch Günter aut Krafft Ulrich aut Grünwald Viktor aut Hadaschik Boris aut Olah Csilla aut Maráz Anikó aut Furka Andrea aut Szűcs Miklós aut Nyirády Péter aut Szarvas Tibor aut http://publicatio.bibl.u-szeged.hu/28568/1/s41598-023-44103-9.pdf Dokumentum-elérés