Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs
Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstan...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
24 No. 18 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms241813749 |
| mtmt: | 34131836 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/28365 |
| LEADER | 02097nab a2200337 i 4500 | ||
|---|---|---|---|
| 001 | publ28365 | ||
| 005 | 20230928084746.0 | ||
| 008 | 230928s2023 hu o 0|| Angol d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms241813749 |2 doi | |
| 024 | 7 | |a 34131836 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 2 | |a Senobar Tahaei Seyyed Ashkan | |
| 245 | 1 | 0 | |a Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs |h [elektronikus dokumentum] / |c Senobar Tahaei Seyyed Ashkan |
| 260 | |c 2023 | ||
| 300 | |a 16 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 24 No. 18 | |
| 520 | 3 | |a Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies. | |
| 650 | 4 | |a Kémiai tudományok | |
| 650 | 4 | |a Farmakológia és gyógyszerészet | |
| 700 | 0 | 1 | |a Kulmány Ágnes |e aut |
| 700 | 0 | 1 | |a Minorics Renáta |e aut |
| 700 | 0 | 1 | |a Kiss Anita |e aut |
| 700 | 0 | 1 | |a Szabó Zoltán |e aut |
| 700 | 0 | 1 | |a Germán Péter |e aut |
| 700 | 0 | 1 | |a Szebeni Gábor |e aut |
| 700 | 0 | 1 | |a Gémes Nikolett |e aut |
| 700 | 0 | 1 | |a Mernyák Erzsébet |e aut |
| 700 | 0 | 1 | |a Zupkó István |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/28365/1/ijms-24-13749.pdf |z Dokumentum-elérés |