Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo
The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO metabolic pathways, we analyzed the myocardial...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
24 No. 7 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms24076443 |
| mtmt: | 33753546 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/27024 |
| LEADER | 02305nab a2200277 i 4500 | ||
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| 005 | 20230424081652.0 | ||
| 008 | 230424s2023 hu o 0|| Angol d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms24076443 |2 doi | |
| 024 | 7 | |a 33753546 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Heger Jacqueline | |
| 245 | 1 | 0 | |a Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo |h [elektronikus dokumentum] / |c Heger Jacqueline |
| 260 | |c 2023 | ||
| 300 | |a 13 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 24 No. 7 | |
| 520 | 3 | |a The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO metabolic pathways, we analyzed the myocardial infarct size (IS) following I/R in female and male MAO-B KO mice in vivo. Method and Results: To induce the deletion of MAO-B, MAO-B KO mice (Myh6 Cre+/MAO-Bfl/fl) and wild-type (WT, Cre-negative MAO-Bfl/fl littermates) were fed with tamoxifen for 2 weeks followed by 10 weeks of normal mice chow. Myocardial infarction (assessed by TTC staining and expressed as a percentage of the area at risk as determined by Evans blue staining)) was induced by 45 min coronary occlusion followed by 120 min of reperfusion. Results: The mortality following I/R was higher in male compared to female mice, with the lowest mortality found in MAO-B KO female mice. IS was significantly higher in male WT mice compared to female WT mice. MAO-B KO reduced IS in male mice but had no further impact on IS in female MAO-B KO mice. Interestingly, there was no difference in the plasma estradiol levels among the groups. Conclusion: The cardiomyocyte-specific knockout of MAO-B protects male mice against acute myocardial infarction but had no effect on the infarct size in female mice. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Szabados Tamara |e aut |
| 700 | 0 | 1 | |a Brosinsky Paulin |e aut |
| 700 | 0 | 1 | |a Bencsik Péter |e aut |
| 700 | 0 | 1 | |a Ferdinandy Péter |e aut |
| 700 | 0 | 1 | |a Schulz Rainer |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/27024/1/Heger.pdf |z Dokumentum-elérés |