Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation a novel arrhythmogenic mechanism /
Atrial fibrillation (AF) is associated with altered cAMP/PKA signaling and an AF-promoting reduction of L-type Ca2+-current (ICa,L), the mechanisms of which are poorly understood. Cyclic-nucleotide phosphodiesterases (PDEs) degrade cAMP and regulate PKA-dependent phosphorylation of key calcium-handl...
Elmentve itt :
Szerzők: |
Grammatika Pavlidou Nefeli Dobrev Shokoufeh Beneke Kira Reinhardt Franziska Pecha Simon Jacquet Eric Abu-Taha Issam H. Schmidt Constanze Voigt Niels Kamler Markus Schnabel Renate B. Baczkó István Garnier Anne Reichenspurner Hermann Nikolaev Viacheslav O. Dobrev Dobromir Molina Cristina E. |
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Dokumentumtípus: | Cikk |
Megjelent: |
2023
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Sorozat: | EUROPEAN HEART JOURNAL
44 No. 27 |
Tárgyszavak: | |
doi: | 10.1093/eurheartj/ehad086 |
mtmt: | 33660570 |
Online Access: | http://publicatio.bibl.u-szeged.hu/26593 |
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