Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation a novel arrhythmogenic mechanism /

Atrial fibrillation (AF) is associated with altered cAMP/PKA signaling and an AF-promoting reduction of L-type Ca2+-current (ICa,L), the mechanisms of which are poorly understood. Cyclic-nucleotide phosphodiesterases (PDEs) degrade cAMP and regulate PKA-dependent phosphorylation of key calcium-handl...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Grammatika Pavlidou Nefeli
Dobrev Shokoufeh
Beneke Kira
Reinhardt Franziska
Pecha Simon
Jacquet Eric
Abu-Taha Issam H.
Schmidt Constanze
Voigt Niels
Kamler Markus
Schnabel Renate B.
Baczkó István
Garnier Anne
Reichenspurner Hermann
Nikolaev Viacheslav O.
Dobrev Dobromir
Molina Cristina E.
Dokumentumtípus: Cikk
Megjelent: 2023
Sorozat:EUROPEAN HEART JOURNAL 44 No. 27
Tárgyszavak:
doi:10.1093/eurheartj/ehad086

mtmt:33660570
Online Access:http://publicatio.bibl.u-szeged.hu/26593

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