Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration

Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration

Background: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms.Methods: Twenty cancer centers in the International...

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Elmentve itt :
Bibliográfiai részletek
Szerzők: Claussen Carla Sophie
Moir Graeme
Bechara Falk G.
Orlando Antonio
Matteucci Paolo
Mowatt David
Clover Anthony James P.
Mascherini Matteo
Gehl Julie
Muir Tobian
Sersa Gregor
Groselj Ales
Odili Joy
Kis Erika
et al
Dokumentumtípus: Cikk
Megjelent: 2022
Sorozat:JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT 20 No. 4
Tárgyszavak:
Klinikai orvostan
doi:10.1111/ddg.14699

mtmt:33448753
Online Access:http://publicatio.bibl.u-szeged.hu/26529
Leíró adatok
Tartalmi kivonat:Background: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms.Methods: Twenty cancer centers in the International Network for Sharing Practices on Electrochemotherapy (InspECT) prospectively collected data. ECT was performed following ESOPE protocol. Response was evaluated by lesion size development. Pain, symptoms, performance status (ECOG-Index) and health status (EQ-5D questionnaire) were evaluated.Results: 716 patients with ulcerated (n = 302) and non-ulcerated (n = 414) cutaneous tumors and metastases were included (minimum follow-up of 45 days). Non-ulcerated lesions responded to ECT better than ulcerated lesions (complete response 65 % vs. 51 %, p = 0.0061). Only 38 % (115/302) with ulcerated lesions before ECT presented with ulcerated lesions at final follow-up. Patients with ulcerated lesions reported higher pain and more severe symptoms compared to non- ulcerated lesions, which significantly and continuously improved following ECT. In non-ulcerated lesions however, pain spiked during the treatment. No serious adverse events were reported.Conclusions: ECT is a safe and effective local treatment for cutaneous tumors. While ECT improves symptoms especially in patients with ulcerated lesions, data suggest the implementation of a perioperative pain management in non-ulcerated lesions during ECT.
Terjedelem/Fizikai jellemzők:470-481
ISSN:1610-0379

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