Survival of Myocardial Infarction Patients with Diabetes Mellitus at the Invasive Era (Results from the Városmajor Myocardial Infarction Registry)

Introduction. Due to the lifelong nature of diabetes mellitus (DM), it has been demonstrated to have significant effects on patients’ morbidity and mortality. The present study aimed to assess the effects of DM on the clinical outcome and survival in patients who underwent percutaneous coronary inte...

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Bibliographic Details
Main Authors: Skoda Réka
Nemes Attila
Bárczi György
Vágó Hajnalka
Ruzsa Zoltán
Édes István F.
Oláh Attila
Kosztin Annamária
Dinya Elek
Merkely Béla
Becker Dávid
Format: Article
Published: 2023
Series:JOURNAL OF CLINICAL MEDICINE 12 No. 3
Subjects:
doi:10.3390/jcm12030917

mtmt:33592449
Online Access:http://publicatio.bibl.u-szeged.hu/26353
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520 3 |a Introduction. Due to the lifelong nature of diabetes mellitus (DM), it has been demonstrated to have significant effects on patients’ morbidity and mortality. The present study aimed to assess the effects of DM on the clinical outcome and survival in patients who underwent percutaneous coronary intervention (PCI) due to myocardial infarction (MI) and to examine the relationship of DM to the type of the MI and to left ventricular (LV) and renal functions. Methods. A total of 12,270 patients with ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI) were revascularized at our Institution between 2005 and 2013. In this pool of patients, 4388 subjects had DM, while 7018 cases had no DM. Results. In both STEMI and NSTEMI, the 30-day and 1-year survival were worse in diabetic patients as compared to non-diabetic cases. In the patients with DM, NSTEMI showed worse prognosis within 1-year than STEMI similarly to non-diabetic subjects. Regarding survival, the presence of DM seemed to be more important than the type of MI. Regardless of the presence of DM, reduced LV function was a maleficent prognostic sign and DM significantly reduced the prognosis both in case of reduced and normal LV function. Survival is primarily affected by LV function, rather than DM. Worse renal function is associated with worse 30-day and 1-year survival in both cases with and without DM. Considering different renal functions, the presence of DM worsens both short- and long-term survival. Survival is primarily affected by renal function, rather than DM. Conclusions. The results from a high-volume PCI center confirm significant the negative prognostic impact of DM on survival in MI patients. DM is a more important prognostic factor than the type of the MI. However, survival is primarily affected by LV and renal functions, rather than DM. These results could highlight our attention on the importance of recent DM treatment with new drugs including SGLT-2 inhibitors and GLP-1 antagonists with beneficial effects on survival. 
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700 0 1 |a Nemes Attila  |e aut 
700 0 1 |a Bárczi György  |e aut 
700 0 1 |a Vágó Hajnalka  |e aut 
700 0 1 |a Ruzsa Zoltán  |e aut 
700 0 1 |a Édes István F.  |e aut 
700 0 1 |a Oláh Attila  |e aut 
700 0 1 |a Kosztin Annamária  |e aut 
700 0 1 |a Dinya Elek  |e aut 
700 0 1 |a Merkely Béla  |e aut 
700 0 1 |a Becker Dávid  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/26353/1/Skoda2023.pdf  |z Dokumentum-elérés