Milk-Derived Carbon Quantum Dots Study of Biological and Chemical Properties Provides Evidence of Toxicity /

Carbon dots (CDs) are carbon-based zero-dimensional nanomaterials that can be prepared from a number of organic precursors. In this research, they are prepared using fat-free UHT cow milk through the hydrothermal method. FTIR analysis shows C=O and C-H bond presence, as well as nitrogen-based bond l...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Shabbir Hasan
Wojtaszek Konrad
Rutkowski Bogdan
Csapó Edit
Bednarski Marek
Adamiec Anita
Głuch‑Lutwin Monika
Mordyl Barbara
Druciarek Julia
Kotańska Magdalena
Ozga Piotr
Wojnicki Marek
Dokumentumtípus: Cikk
Megjelent: 2022
Sorozat:MOLECULES 27 No. 24
Tárgyszavak:
doi:10.3390/molecules27248728

mtmt:33300881
Online Access:http://publicatio.bibl.u-szeged.hu/25755
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520 3 |a Carbon dots (CDs) are carbon-based zero-dimensional nanomaterials that can be prepared from a number of organic precursors. In this research, they are prepared using fat-free UHT cow milk through the hydrothermal method. FTIR analysis shows C=O and C-H bond presence, as well as nitrogen-based bond like C-N, C=N and –NH2 presence in CDs, while the absorption spectra show the absorption band at 280 ± 3 nm. Next, the Biuret test was performed, with the results showing no presence of unreacted proteins in CDs. It can be said that all proteins are converted in CDs. Photo luminance spectra shows the emission of CDs is 420 nm and a toxicity study of CDs was performed. The Presto Blue method was used to test the toxicity of CDs for murine hippocampal cells. CDs at a concentration of 4 mg/mL were hazardous independent of synthesis time, while the toxicity was higher for lower synthesis times of 1 and 2 h. When the concentration is reduced in 1 and 2 h synthesized CDs, the cytotoxic effect also decreases significantly, ensuring a survival rate of 60–80%. However, when the synthesis time of CDs is increased, the cytotoxic effect decreases to a lesser extent. The CDs with the highest synthesis time of 8 h do not show a cytotoxic effect above 60%. The cytotoxicity study shows that CDs may have a concentration and time–dependent cytotoxic effect, reducing the number of viable cells by 40%. 
650 4 |a Kémiai tudományok 
700 0 1 |a Wojtaszek Konrad  |e aut 
700 0 1 |a Rutkowski Bogdan  |e aut 
700 0 1 |a Csapó Edit  |e aut 
700 0 1 |a Bednarski Marek  |e aut 
700 0 1 |a Adamiec Anita  |e aut 
700 0 1 |a Głuch‑Lutwin Monika  |e aut 
700 0 1 |a Mordyl Barbara  |e aut 
700 0 1 |a Druciarek Julia  |e aut 
700 0 1 |a Kotańska Magdalena  |e aut 
700 0 1 |a Ozga Piotr  |e aut 
700 0 1 |a Wojnicki Marek  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/25755/1/molecules-27-08728.pdf  |z Dokumentum-elérés