Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci
Spreading depolarizations (SDs) indicate injury progression and predict worse clinical outcome in acute brain injury. We demonstrate in rodents that acute brain swelling upon cerebral ischemia impairs astroglial glutamate clearance and increases the tissue area invaded by SD. The cytotoxic extracell...
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| Format: | Article |
| Published: |
2022
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| Series: | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
42 No. 4 |
| Subjects: | |
| doi: | 10.1177/0271678X211040056 |
| mtmt: | 32165015 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/25658 |