02452nab a2200385 i 4500 publ24521 20220628083700.0 220613s2020 hu o 0|| Angol d 1352-4585 10.1177/1352458519845844 doi 31040420 mtmt SZTE Publicatio Repozitórium hun Angol Leurs C. E. Kappa free light chains is a valid tool in the diagnostics of MS [elektronikus dokumentum] : A large multicenter study / Leurs C. E. 2020 912-923 MULTIPLE SCLEROSIS JOURNAL 26 No. 8 To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS).We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes.The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB.Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. Idegtudományok (benne pszichofiziológia) Twaalfhoven Ham aut Lissenberg-Witte B. I. aut van Pesch V. aut Dujmovic I. aut Drulovic J. aut Castellazzi M. aut Bellini T. aut Pugliatti M. aut Kuhle J. aut Villar L. M. aut Alvarez-Cermeño J. C. aut Vécsei László aut Rajda Cecília aut Fazekas F. aut http://publicatio.bibl.u-szeged.hu/24521/1/Kappafreelightchains.pdf Dokumentum-elérés