Effect of Pre-Hospital Ticagrelor During the First 24 Hours After Primary PCI in Patients With ST-Segment Elevation Myocardial Infarction The ATLANTIC-H Analysis /
OBJECTIVES: The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST el...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
|
| Sorozat: | JACC-CARDIOVASCULAR INTERVENTIONS
9 No. 7 |
| Tárgyszavak: | |
| doi: | 10.1016/j.jcin.2015.12.024 |
| mtmt: | 3040115 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/24153 |
| LEADER | 03518nab a2200397 i 4500 | ||
|---|---|---|---|
| 001 | publ24153 | ||
| 005 | 20220420132603.0 | ||
| 008 | 220420s2016 hu o 0|| Angol d | ||
| 022 | |a 1936-8798 | ||
| 024 | 7 | |a 10.1016/j.jcin.2015.12.024 |2 doi | |
| 024 | 7 | |a 3040115 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Montalescot Gilles | |
| 245 | 1 | 0 | |a Effect of Pre-Hospital Ticagrelor During the First 24 Hours After Primary PCI in Patients With ST-Segment Elevation Myocardial Infarction |h [elektronikus dokumentum] : |b The ATLANTIC-H Analysis / |c Montalescot Gilles |
| 260 | |c 2016 | ||
| 300 | |a 646-656 | ||
| 490 | 0 | |a JACC-CARDIOVASCULAR INTERVENTIONS |v 9 No. 7 | |
| 520 | 3 | |a OBJECTIVES: The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery study). BACKGROUND: The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). METHODS: The ATLANTIC-H24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction grade 3 flow, >/=70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. RESULTS: Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%, p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%, p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%, p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. CONCLUSIONS: The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality. (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery [ATLANTIC, NCT01347580]). | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 2 | |a van 't Hof Arnoud W. |e aut |
| 700 | 0 | 2 | |a Bolognese Leonardo |e aut |
| 700 | 0 | 2 | |a Cantor Warren J. |e aut |
| 700 | 0 | 2 | |a Cequier Angel |e aut |
| 700 | 0 | 2 | |a Chettibi Mohamed |e aut |
| 700 | 0 | 2 | |a Collet Jean-Philippe |e aut |
| 700 | 0 | 2 | |a Goodman Shaun G. |e aut |
| 700 | 0 | 2 | |a Hammett Christopher J. |e aut |
| 700 | 0 | 2 | |a Huber Kurt |e aut |
| 700 | 0 | 2 | |a Merkely Béla Péter |e aut |
| 700 | 0 | 2 | |a Kollaborációs szervezet: ATLANTIC Investigators |e aut |
| 700 | 0 | 2 | |a Ungi Imre |e aut |
| 700 | 0 | 2 | |a Horváth Iván |e aut |
| 700 | 0 | 2 | |a Édes István |e aut |
| 700 | 0 | 2 | |a Mártai István |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/24153/1/Montalescot.pdf |z Dokumentum-elérés |