Systemic administration of ivabradine, a hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, blocks spontaneous absence seizures

Objective Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to be involved in the generation of absence seizures (ASs), and there is evidence that cortical and thalamic HCN channel dysfunctions may have a proabsence role. Many HCN channel blockers are available, but their...

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Bibliographic Details
Main Authors: Iacone Yasmine
Morais Tatiana P.
David Francois
Delicata Francis
Sandle Joanna
Raffai Tímea
Parri Harri Rheinallt
Weisser Johan Juhl
Bundgaard Christoffer
Klewe Ib Vestergaard
Tamás Gábor
Thomsen Morten Skøtt
Crunelli Vincenzo
Lőrincz László Magor
Format: Article
Published: 2021
Series:EPILEPSIA 62 No. 7
Subjects:
doi:10.1111/epi.16926

mtmt:32037613
Online Access:http://publicatio.bibl.u-szeged.hu/23324

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