Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic and metabotropic output of neocortical neurog...

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Bibliographic Details
Main Authors: Ozsvár Attila
Komlósi Gergely
Oláh Gáspár
Baka Judith
Molnár Gábor
Tamás Gábor
Format: Article
Published: 2021
Series:ELIFE 10
Subjects:
doi:10.7554/eLife.65634

mtmt:32186919
Online Access:http://publicatio.bibl.u-szeged.hu/22447
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520 3 |a Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic and metabotropic output of neocortical neurogliaform cells (NGFCs) using electrophysiological and anatomical methods in the rat cerebral cortex. These experiments revealed that GABA receptors are activated outside release sites and confirmed coactivation of putative NGFCs in superficial cortical layers in vivo. Triple recordings from presynaptic NGFCs converging to a postsynaptic neuron revealed sublinear summation of ionotropic GABA(A) responses and linear summation of metabotropic GABA(B) responses. Based on a model combining properties of volume transmission and distributions of all NGFC axon terminals, we predict that in 83% of cases one or two NGFCs can provide input to a point in the neuropil. We suggest that interactions of metabotropic GABAergic responses remain linear even if most superficial layer interneurons specialized to recruit GABA(B) receptors are simultaneously active. 
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700 0 1 |a Oláh Gáspár  |e aut 
700 0 1 |a Baka Judith  |e aut 
700 0 1 |a Molnár Gábor  |e aut 
700 0 1 |a Tamás Gábor  |e aut 
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