The effects of CRF and urocortins on the preference for social novelty of mice

The aim of the present study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (UCN 1, UCN 2 and UCN 3) and their receptors (CRF1 and CRF2) in the preference for social novelty of mice. Male CFLP mice were administered intracerebroventricularly (ICV) with CRF, UCN 1,...

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Bibliographic Details
Main Authors: Bagosi Zsolt
Czebely-Lenart András
Karasz Gergely
Csabafi Krisztina
Jászberényi Miklós
Telegdy Gyula
Format: Article
Published: 2017
Series:BEHAVIOURAL BRAIN RESEARCH 324
doi:10.1016/j.bbr.2017.02.009

mtmt:3280538
Online Access:http://publicatio.bibl.u-szeged.hu/21060
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490 0 |a BEHAVIOURAL BRAIN RESEARCH  |v 324 
520 3 |a The aim of the present study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (UCN 1, UCN 2 and UCN 3) and their receptors (CRF1 and CRF2) in the preference for social novelty of mice. Male CFLP mice were administered intracerebroventricularly (ICV) with CRF, UCN 1, UCN 2 or UCN 3 and/or antalarmin or astressin 2B, selective antagonists of CRF1 receptor and CRF2 receptor, respectively. The mice were investigated in a Crawley social interaction test arena consisting of three chambers: an unknown female was set in the first chamber and a known female, with which the male was familiarized previously for 24 h, was set in the third chamber. First the tested male was habituated with the middle chamber for 5 min and then allowed to explore the remaining chambers for 5 min, during which the number of entries and the time of interaction were measured. CRF decreased significantly the number of entries and the time of interaction with the unknown female, but not the known female. UCN 1 decreased significantly the number of entries into the chamber of the unknown female, but not the known female, without changing the time of interaction. All decreasing effects were reversed by antalarmin, but not astressin 2B. UCN 2 and UCN 3 didn't influence significantly any of the parameters. The present study suggests that CRF and UCN 1 decrease the preference for social novelty by activating CRF1 receptor, while UCN 2 and UCN 3, activating selectively CRF2 receptor, do not participate to male-female interaction. (C) 2017 Elsevier B.V. All rights reserved. 
700 0 2 |a Czebely-Lenart András  |e aut 
700 0 2 |a Karasz Gergely  |e aut 
700 0 2 |a Csabafi Krisztina  |e aut 
700 0 2 |a Jászberényi Miklós  |e aut 
700 0 2 |a Telegdy Gyula  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/21060/1/BagosiZs.-TheeffectsofCRF.....pdf  |z Dokumentum-elérés