Neurovascular Inflammaging in Health and Disease
Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cog...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
|
| Sorozat: | CELLS
9 No. 7 |
| doi: | 10.3390/cells9071614 |
| mtmt: | 31401608 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/20537 |
| LEADER | 02008nab a2200277 i 4500 | ||
|---|---|---|---|
| 001 | publ20537 | ||
| 005 | 20221026135743.0 | ||
| 008 | 210204s2020 hu o 0|| zxx d | ||
| 022 | |a 2073-4409 | ||
| 024 | 7 | |a 10.3390/cells9071614 |2 doi | |
| 024 | 7 | |a 31401608 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Mészáros Ádám | |
| 245 | 1 | 0 | |a Neurovascular Inflammaging in Health and Disease |h [elektronikus dokumentum] / |c Mészáros Ádám |
| 260 | |c 2020 | ||
| 300 | |a Terjedelem:23-Azonosító:1614 | ||
| 490 | 0 | |a CELLS |v 9 No. 7 | |
| 520 | 3 | |a Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1 beta, IL-18), inflammation is initiated, resulting in tissue injury in various organs, the brain and the spinal cord included. Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position. In this review, we discuss the inflammatory changes in normal aging and summarize the current knowledge on the role of inflammasomes and contributing mechanisms in common CNS diseases, namely Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke, all of which occur more frequently with aging. | |
| 700 | 0 | 1 | |a Molnár Kinga |e aut |
| 700 | 0 | 1 | |a Nógrádi Bernát |e aut |
| 700 | 0 | 1 | |a Hernadi Zsófia |e aut |
| 700 | 0 | 2 | |a Nyúl-Tóth Ádám |e aut |
| 700 | 0 | 2 | |a Wilhelm Imola Mária |e aut |
| 700 | 0 | 2 | |a Krizbai István Adorján |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/20537/1/cells-09-01614.pdf |z Dokumentum-elérés |