Liver-on-a-Chip‒Magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor

Liver-on-a-Chip‒Magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor

Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)...

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Bibliographic Details
Main Authors: Decsi Balázs
Krammer Réka
Hegedűs Kristóf
Ender Ferenc
Gyarmati Benjámin Sándor
Szilágyi András Ferenc
Tőtős Róbert
Katona Gabriel
Paizs Csaba
Balogh György Tibor
Poppe László
Balogh Weiser Diána
Format: Article
Published: 2019
Series:MICROMACHINES 10 No. 10
doi:10.3390/mi10100668

mtmt:30819660
Online Access:http://publicatio.bibl.u-szeged.hu/18860
Description
Summary:Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).
Physical Description:Azonosító: 668-Terjedelem: 13 p
ISSN:2072-666X

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