Design of a colicin E7 based chimeric zinc-finger nuclease
Colicin E7 is a natural bacterial toxin. Its nuclease domain (NColE7) enters the target cell and kills it by digesting the nucleic acids. The HNH-motif as the catalytic centre of NColE7 at the C-terminus requires the positively charged N-terminal loop for the nuclease activity - offering opportuniti...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2014
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| Sorozat: | JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
28 No. 8 |
| doi: | 10.1007/s10822-014-9765-8 |
| mtmt: | 2719874 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18463 |