Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors
In order to obtain novel pharmacological tools and to investigate a multitargeting analgesic strategy, the CB1 and CB2 cannabinoid receptor agonist JWH-018 was conjugated with the opiate analgesic oxycodone or with an enkephalin related tetrapeptide. The opioid and cannabinoid pharmacophores were co...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
178 |
| doi: | 10.1016/j.ejmech.2019.05.037 |
| mtmt: | 30750987 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18007 |