02125nab a2200373 i 4500 publ17550 20191205085941.0 191205s2015 hu o 0|| zxx d 1521-6616 10.1016/j.clim.2015.09.007 doi 3119532 mtmt SZTE Publicatio Repozitórium hun zxx Zhao Jian Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus [elektronikus dokumentum] / Zhao Jian 2015 157-162 CLINICAL IMMUNOLOGY 161 No. 2 Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE. © 2015 Elsevier Inc. Wu Hui aut Langefeld Carl D. aut Kaufman Kenneth M. aut Kelly Jennifer A. aut Börcsökné Endreffy Emőke aut Kovács László aut Bae Sang-Cheol aut Alarcón-Riquelme Marta E. aut Alarcón Graciela S. aut Anaya Juan-Manuel aut Criswell Lindsey A. aut Freedman Barry I. aut Kamen Diane L. aut Gilkeson Gary S. aut http://publicatio.bibl.u-szeged.hu/17550/1/ZhaoJImmunol.pdf Dokumentum-elérés