01608nab a2200253 i 4500 publ17098 20191014095324.0 191014s2019 hu o 0|| zxx d 1233-9687 10.5114/pjp.2019.87105 doi 30842250 mtmt SZTE Publicatio Repozitórium hun zxx Cserni Gábor Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis. [elektronikus dokumentum] / Cserni Gábor 2019 139-143 POLISH JOURNAL OF PATHOLOGY 70 No. 2 We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth. Serfőző Orsolya aut Ambrózay Éva aut Markó László aut Krenács László aut http://publicatio.bibl.u-szeged.hu/17098/1/PolJPathol-2019-70-139-143-SpontRegrTNBC.pdf Dokumentum-elérés