Combined pharmacological block of I-Kr and I-Ks increases short-term QT interval variability and provokes torsades de pointes
Background and purpose: Assessing the proarrhythmic potential of compounds during drug development is essential. However, reliable prediction of drug-induced torsades de pointes arrhythmia (TdP) remains elusive. Along with QT interval prolongation, assessment of the short-term variability of the QT...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2007
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| Sorozat: | BRITISH JOURNAL OF PHARMACOLOGY
151 No. 7 |
| doi: | 10.1038/sj.bjp.0707297 |
| mtmt: | 1132579 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/16203 |