Corneal Langerhans cell and dry eye examinations in ankylosing spondylitis

APCs of the ocular surface, including corneal Langerhans cells (LCs), offer the opportunity to gain insight into the activity of innate immunity. We examined corneal LCs and dry eye parameters in ankylosing spondylitis (AS). Twenty-four AS patients with varying degrees of disease activity and 24 hea...

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Main Authors: Marsovszky László
Németh János Tibor
Resch Miklós
Toldi Gergely
Legány Nóra
Kovács László
Balog Attila
Format: Article
Published: 2014
Series:INNATE IMMUNITY 20 No. 5
doi:10.1177/1753425913498912

mtmt:2443732
Online Access:http://publicatio.bibl.u-szeged.hu/15820
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520 3 |a APCs of the ocular surface, including corneal Langerhans cells (LCs), offer the opportunity to gain insight into the activity of innate immunity. We examined corneal LCs and dry eye parameters in ankylosing spondylitis (AS). Twenty-four AS patients with varying degrees of disease activity and 24 healthy participants were enrolled. Central and peripheral LC numbers, and Langerhans cell morphology (LCM) were assessed with in vivo laser confocal microscopy. In addition, ocular surface disease index, lid parallel conjunctival folds, tear break up time, and Schirmer test were evaluated. LC densities and central LCM were greater in AS patients than in the controls. Moreover, LCM was significantly greater in patients with higher systemic inflammation according to elevated C-reactive protein (CRP). Also, tear production was greatly suppressed in patients with more severe onset of the systemic inflammation according to the Bath Ankylosing Spondylitis Disease Activity Index and elevated CRP. Greater corneal LC density and LCM in AS may reflect an increased activation state of the innate immune system of the cornea in AS, which correlates with the systemic activity of AS even without ocular symptoms. Nonetheless, higher systemic inflammation might impair tear production, and it might partly explain the dry eye mechanism. 
700 0 1 |a Németh János Tibor  |e aut 
700 0 1 |a Resch Miklós  |e aut 
700 0 1 |a Toldi Gergely  |e aut 
700 0 1 |a Legány Nóra  |e aut 
700 0 1 |a Kovács László  |e aut 
700 0 1 |a Balog Attila  |e aut 
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