Adaptive Immunity in Ankylosing Spondylitis Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy. /
Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease. In addition, we also tested short-term T-cell activation characteristics. Measurements were done in 13 AS patients before and during the intravenous therapy w...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2012
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| Sorozat: | CLINICAL AND DEVELOPMENTAL IMMUNOLOGY
2012 |
| doi: | 10.1155/2012/808724 |
| mtmt: | 1754147 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/15815 |
| LEADER | 02054nab a2200289 i 4500 | ||
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| 001 | publ15815 | ||
| 005 | 20190625084307.0 | ||
| 008 | 190625s2012 hu o 0|| zxx d | ||
| 022 | |a 1740-2522 | ||
| 024 | 7 | |a 10.1155/2012/808724 |2 doi | |
| 024 | 7 | |a 1754147 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Szalay Balázs | |
| 245 | 1 | 0 | |a Adaptive Immunity in Ankylosing Spondylitis |h [elektronikus dokumentum] : |b Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy. / |c Szalay Balázs |
| 260 | |c 2012 | ||
| 300 | |a Terjedelem : 8 p-Azonosító: 808724 | ||
| 490 | 0 | |a CLINICAL AND DEVELOPMENTAL IMMUNOLOGY |v 2012 | |
| 520 | 3 | |a Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease. In addition, we also tested short-term T-cell activation characteristics. Measurements were done in 13 AS patients before and during the intravenous therapy with anti-TNF agent infliximab (IFX). Flow cytometry was used to determine T-cell subsets in peripheral blood and their intracellular signaling during activation. The prevalence of Th2 and Th17 cells responsible for the regulation of adaptive immunity was higher in AS than in 9 healthy controls. Although IFX therapy improved patients' condition, immune phenotype did not normalize. Cytoplasmic and mitochondrial calcium responses of CD4+ and CD8+ cells to a specific activation were delayed, while NO generation was increased in AS. NO generation normalized sooner upon IFX than calcium response. These results suggest an abnormal immune phenotype with functional disturbances of CD4+ and CD8+ cells in AS. | |
| 700 | 0 | 1 | |a Mészáros Gergő |e aut |
| 700 | 0 | 1 | |a Cseh Áron |e aut |
| 700 | 0 | 1 | |a Ács Lilla |e aut |
| 700 | 0 | 1 | |a Deák Magdolna |e aut |
| 700 | 0 | 1 | |a Kovács László |e aut |
| 700 | 0 | 1 | |a Vásárhelyi Barna |e aut |
| 700 | 0 | 1 | |a Balog Attila |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/15815/1/SzalayBClinDevelopmentalImmunol2012.pdf |z Dokumentum-elérés |