Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate
A selective continuous-flow (CF) deuterodehalogenation approach is described performed in propylene carbonate, which is considered as one of the greenest solvents. Various CF technologies are known for hydrodehalogenation reactions; however, they are not directly transferable for deuteration transfo...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | GREEN CHEMISTRY
21 No. 5 |
| doi: | 10.1039/c8gc03192d |
| mtmt: | 30638150 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/15784 |
| LEADER | 01688nab a2200229 i 4500 | ||
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| 005 | 20190620100731.0 | ||
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| 022 | |a 1463-9262 | ||
| 024 | 7 | |a 10.1039/c8gc03192d |2 doi | |
| 024 | 7 | |a 30638150 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Orsy György | |
| 245 | 1 | 0 | |a Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate |h [elektronikus dokumentum] / |c Orsy György |
| 260 | |c 2019 | ||
| 300 | |a 956-961 | ||
| 490 | 0 | |a GREEN CHEMISTRY |v 21 No. 5 | |
| 520 | 3 | |a A selective continuous-flow (CF) deuterodehalogenation approach is described performed in propylene carbonate, which is considered as one of the greenest solvents. Various CF technologies are known for hydrodehalogenation reactions; however, they are not directly transferable for deuteration transformations. A novel spherical activated carbon-supported palladium catalyst has been found to be useful for the catalytic deuterodehalogenation of haloarenes. After careful reaction parameter optimization, complete conversion was achieved for bromine-and chlorine-substituted haloarenes. Nonetheless, no deuterium exchange was observed for the fluorine substituent, while iodine-substituted compounds poisoned the catalyst. Importantly, deuterated compounds were obtained with a rate of 3 mg min-1 and the catalyst showed reasonable reusability. Moreover, benzylic amides were also deuterated without any debenzylation side-reaction. | |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 1 | |a Mándity István |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/15784/1/orsy_greenchemistry.pdf |z Dokumentum-elérés |