Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer a multi-institutional study /
BACKGROUND: Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agr...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2018
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| Sorozat: | BREAST CANCER RESEARCH AND TREATMENT
171 No. 1 |
| doi: | 10.1007/s10549-018-4825-8 |
| mtmt: | 3376690 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/14419 |
| LEADER | 02810nab a2200277 i 4500 | ||
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| 001 | publ14419 | ||
| 005 | 20190116144641.0 | ||
| 008 | 190116s2018 hu o 0|| angol d | ||
| 022 | |a 0167-6806 | ||
| 024 | 7 | |a 10.1007/s10549-018-4825-8 |2 doi | |
| 024 | 7 | |a 3376690 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a O'Loughlin Mark | |
| 245 | 1 | 0 | |a Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer |h [elektronikus dokumentum] : |b a multi-institutional study / |c O'Loughlin Mark |
| 260 | |c 2018 | ||
| 300 | |a 1-9 | ||
| 490 | 0 | |a BREAST CANCER RESEARCH AND TREATMENT |v 171 No. 1 | |
| 520 | 3 | |a BACKGROUND: Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast pathologists across Europe scoring sTILs on H&E-stained sections without software, an approach that is easily applied in clinical practice. The association between sTILs and response to anthracycline-taxane NACT was also examined. METHODOLOGY: Pathologists from the European Working Group for Breast Screening Pathology scored sTILs in 84 slides from 75 TNBCs using the immune-oncology biomarker working group guidance in two circulations. There were 16 participants in the first and 19 in the second circulation. RESULTS: Moderate agreement was achieved for absolute sTILs scores (intraclass correlation coefficient (ICC) = 0.683, 95% CI 0.601-0.767, p-value < 0.001). Agreement was less when a 25% threshold was used (ICC 0.509, 95% CI 0.416-0.614, p-value < 0.001) and for lymphocyte predominant breast cancer (LPBC) (ICC 0.504, 95% CI 0.412-0.610, p-value < 0.001). Intra-observer agreement was strong for absolute sTIL values (Spearman rho = 0.727); fair for sTILs >/= 25% (kappa = 0.53) and for LPBC (kappa = 0.49), but poor for sTILs as 10% increments (kappa = 0.24). Increasing sTILs was significantly associated with an increased likelihood of a pathological complete response (pCR) on multivariable analysis. CONCLUSION: Increasing sTILs in TNBCs improves the likelihood of a pCR. However, inter-observer agreement is such that H&E-based assessment is not sufficiently reproducible for clinical application. Other methodologies should be explored, but may be at the cost of ease of application. | |
| 700 | 0 | 1 | |a Andreu Xavier |e aut |
| 700 | 0 | 1 | |a Bianchi Simonetta |e aut |
| 700 | 0 | 1 | |a Chemielik Ewa |e aut |
| 700 | 0 | 1 | |a Cordoba Alicia |e aut |
| 700 | 0 | 1 | |a Cserni Gábor |e aut |
| 700 | 0 | 1 | |a Kulka Janina |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/14419/1/3376690.pdf |z Dokumentum-elérés |