Presymptomatically applied AMPA receptor antagonist prevents calcium increase in vulnerable type of motor axon terminals of mice modeling amyotrophic lateral sclerosis

Presymptomatically applied AMPA receptor antagonist prevents calcium increase in vulnerable type of motor axon terminals of mice modeling amyotrophic lateral sclerosis

Increased intracellular calcium (Ca), which might be the consequence of an excess influx through Ca-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, plays a crucial role in degeneration of motor neurons. Previously we demonstrated that the presymptomatic applicati...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Patai Roland
Paizs Melinda
Tortarolo Massimo
Bendotti Caterina
Obál Caterina
Engelhardt József István
Siklós László
Dokumentumtípus: Cikk
Megjelent: Elsevier 2017
Sorozat:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1863
doi:10.1016/j.bbadis.2017.05.016

mtmt:3226258
Online Access:http://publicatio.bibl.u-szeged.hu/13525

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