02422nab a2200433 i 4500 publ13029 20200326135452.0 180227s2016 hu o 0|| zxx d 1219-4956 10.1007/s12253-015-9969-9 doi 2927668 mtmt SZTE Publicatio Repozitórium hun zxx Tóbiás Bálint Genetic alterations in Hungarian patients with papillary thyroid cancer [elektronikus dokumentum] / Tóbiás Bálint Springer Netherlands 2016 27-33 PATHOLOGY AND ONCOLOGY RESEARCH 22 No. 1 The incidence of thyroid cancers is increasing worldwide. Some somatic oncogene mutations (BRAF, NRAS, HRAS, KRAS) as well as gene translocations (RET/PTC, PAX8/PPAR-gamma) have been associated with the development of thyroid cancer. In our study, we analyzed these genetic alterations in 394 thyroid tissue samples (197 papillary carcinomas and 197 healthy). The somatic mutations and translocations were detected by Light Cycler melting method and Real-Time Polymerase Chain Reaction techniques, respectively. In tumorous samples, 86 BRAF (44.2 %), 5 NRAS (3.1 %), 2 HRAS (1.0 %) and 1 KRAS (0.5 %) mutations were found, as well as 9 RET/PTC1 (4.6 %) and 1 RET/PTC3 (0.5 %) translocations. No genetic alteration was seen in the non tumorous control thyroid tissues. No correlation was detected between the genetic variants and the pathological subtypes of papillary cancer as well as the severity of the disease. Our results are only partly concordant with the data found in the literature. Halászlaki Csaba aut Balla Bernadett aut Kósa János aut Árvai Kristóf aut Horváth Péter aut Takács István aut Nagy Zsolt aut Horváth Evelin aut Horányi János aut Járay Balázs aut Székely Eszter aut Székely Tamás aut Győri Gabriella aut Putz Zsuzsanna aut Dank Magdolna aut Valkusz Zsuzsanna aut Vasas Béla aut Iványi Béla aut Lakatos Péter aut http://publicatio.bibl.u-szeged.hu/13029/2/10.1007_s12253-015-9969-9.pdf Dokumentum-elérés