PPIs prevent aspirin-induced gastrointestinal bleeding better than H2RAs a systematic review and meta-analysis /

Background & Aims: Aspirin is one of the most widely used medication for its analgesic and anti-platelet properties and thus a major cause for gastrointestinal (GI) bleeding. This study compared the preventive effect of histamine-2 receptor antagonists (H2RAs) and proton-pump inhibitors (PPIs) a...

Full description

Saved in:
Bibliographic Details
Main Authors: Szabó Imre
Mátics Róbert
Hegyi Péter
Garami András
Illés Anita
Sarlós Patrícia
Bajor Judit
Szücs Ákos
Mosztbacher Dóra
Márta Katalin
Szemes Kata
Csekő Kata
Kővári Bálint
Rumbus Zoltán
Vincze Áron
Format: Article
Published: 2017
Series:JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES 26 No. 4
doi:10.15403/jgld.2014.1121.264.hra

mtmt:3307926
Online Access:http://publicatio.bibl.u-szeged.hu/12816
LEADER 02894nab a2200373 i 4500
001 publ12816
005 20200320160634.0
008 180131s2017 hu o 0|| zxx d
022 |a 1841-8724 
024 7 |a 10.15403/jgld.2014.1121.264.hra  |2 doi 
024 7 |a 3307926  |2 mtmt 
040 |a SZTE Publicatio Repozitórium  |b hun 
041 |a zxx 
100 1 |a Szabó Imre 
245 1 0 |a PPIs prevent aspirin-induced gastrointestinal bleeding better than H2RAs  |h [elektronikus dokumentum] :  |b a systematic review and meta-analysis /  |c  Szabó Imre 
260 |c 2017 
300 |a 395-402 
490 0 |a JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES  |v 26 No. 4 
520 3 |a Background & Aims: Aspirin is one of the most widely used medication for its analgesic and anti-platelet properties and thus a major cause for gastrointestinal (GI) bleeding. This study compared the preventive effect of histamine-2 receptor antagonists (H2RAs) and proton-pump inhibitors (PPIs) against chronic low-dose aspirin (LDA)-related GI bleeding and ulcer formation. Methods: Electronic databases of Pubmed, Embase and Cochrane Central Register of Controlled Trials were searched for human observations (randomised controlled trials and observational studies) comparing the long term effects of PPIs and H2RAs treatment in the prevention of GI bleeding or ulcer formation in patients on chronic LDA treatment listed up till September 30, 2016. Two independent authors searched databases using PICO questions (aspirin, H2RA, PPI, GI bleeding or ulcer), and reviewed abstracts and articles for comprehensive studies keeping adequate study quality. Data of weighted odds ratios were statistically evaluated using Comprehensive Metaanalysis (Biostat, Inc., Engelwood, MJ, USA), potential bias was checked. Results: Nine studies for GI bleeding and eight studies for ulcer formation were found meeting inclusion criteria, altogether 1,879 patients were included into review. The H2RAs prevented less effectively LDArelated GI bleeding (OR=2.102, 95% CI: 1.008-4.385, p<0.048) and ulcer formation (OR=2.257, 95% CI: 1.277-3.989, p<0.005) than PPIs. Conclusion: The meta-analysis showed that H2RAs were less effective in the prevention of LDA-related GI bleeding and ulcer formation suggesting the preferable usage of PPIs in case of tolerance. 
700 0 1 |a Mátics Róbert  |e aut 
700 0 1 |a Hegyi Péter  |e aut 
700 0 1 |a Garami András  |e aut 
700 0 1 |a Illés Anita  |e aut 
700 0 1 |a Sarlós Patrícia  |e aut 
700 0 1 |a Bajor Judit  |e aut 
700 0 1 |a Szücs Ákos  |e aut 
700 0 1 |a Mosztbacher Dóra  |e aut 
700 0 1 |a Márta Katalin  |e aut 
700 0 1 |a Szemes Kata  |e aut 
700 0 1 |a Csekő Kata  |e aut 
700 0 1 |a Kővári Bálint  |e aut 
700 0 1 |a Rumbus Zoltán  |e aut 
700 0 1 |a Vincze Áron  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/12816/1/x3307926_Szabo_JGLD_u.pdf  |z Dokumentum-elérés