Association between AIRE gene polymorphism and rheumatoid arthritis a systematic review and meta-analysis of case-control studies /
Autoimmune regulator (AIRE) is a transcription factor that functions as a novel player in immunological investigations. In the thymus, it has a pivotal role in the negative selection of naive T-cells during central tolerance. Experimental studies have shown that single nucleotide polymorphism (SNP)...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
Nature Publishing Group
2017
|
| Sorozat: | SCIENTIFIC REPORTS
7 No. 1 |
| doi: | 10.1038/s41598-017-14375-z |
| mtmt: | 3284703 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12811 |
| LEADER | 02650nab a2200349 i 4500 | ||
|---|---|---|---|
| 001 | publ12811 | ||
| 005 | 20200131120129.0 | ||
| 008 | 180131s2017 hu o 0|| zxx d | ||
| 022 | |a 2045-2322 | ||
| 024 | 7 | |a 10.1038/s41598-017-14375-z |2 doi | |
| 024 | 7 | |a 3284703 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Bérczi Bálint | |
| 245 | 1 | 0 | |a Association between AIRE gene polymorphism and rheumatoid arthritis |h [elektronikus dokumentum] : |b a systematic review and meta-analysis of case-control studies / |c Bérczi Bálint |
| 260 | |a Nature Publishing Group |c 2017 | ||
| 300 | |a Azonosító: 14096-Terjedelem: 11 p. | ||
| 490 | 0 | |a SCIENTIFIC REPORTS |v 7 No. 1 | |
| 520 | 3 | |a Autoimmune regulator (AIRE) is a transcription factor that functions as a novel player in immunological investigations. In the thymus, it has a pivotal role in the negative selection of naive T-cells during central tolerance. Experimental studies have shown that single nucleotide polymorphism (SNP) alters transcription of the AIRE gene. SNPs thereby provide a less efficient negative selection, propagate higher survival of autoimmune T-cells, and elevate susceptibility to autoimmune diseases. To date, only rheumatoid arthritis (RA) has been analysed by epidemiological investigations in relation to SNPs in AIRE. In our meta-analysis, we sought to encompass case-control studies and confirm that the association between SNP occurrence and RA. After robust searches of Embase, PubMed, Cochrane Library, and Web of Science databases, we found 19 articles that included five independent studies. Out of 11 polymorphisms, two (rs2075876, rs760426) were common in the five case-control studies. Thus, we performed a meta-analysis for rs2075876 (7145 cases and 8579 controls) and rs760426 (6696 cases and 8164 controls). Our results prove that rs2075876 and rs760426 are significantly associated with an increased risk of RA in allelic, dominant, recessive, codominant heterozygous, and codominant homozygous genetic models. These findings are primarily based on data from Asian populations. | |
| 700 | 0 | 1 | |a Gerencsér Gellért |e aut |
| 700 | 0 | 2 | |a Borbásné Farkas Kornélia |e aut |
| 700 | 0 | 2 | |a Hegyi Péter |e aut |
| 700 | 0 | 2 | |a Veres Gábor |e aut |
| 700 | 0 | 2 | |a Bajor Judit |e aut |
| 700 | 0 | 2 | |a Czopf László |e aut |
| 700 | 0 | 2 | |a Alizadeh Hussain |e aut |
| 700 | 0 | 2 | |a Rakonczay Zoltán, ifj. |e aut |
| 700 | 0 | 2 | |a Vigh Éva |e aut |
| 700 | 0 | 2 | |a Erőss Bálint Mihály |e aut |
| 700 | 0 | 2 | |a Szemes Kata |e aut |
| 700 | 0 | 2 | |a Gyöngyi Zoltán |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/12811/1/3284703_Berczi_Sci_rep_u.pdf |z Dokumentum-elérés |